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付琴

发布者: [发表时间]:2018-04-17 [来源]: [浏览次数]:

 

B400

 

付琴博士,华中科技大学同济医学院药理学系教授。1998年同济医科大学临床医学系本科毕业留校任教至今。2006年获得华中科技大学同济医学院药理学博士学位。2003-2005年德国柏林Max-Delbrueck分子医学中心访问学者;2011-2014年美国伊利诺伊大学香槟分校和加州大学戴维斯分校博士后。

研究方向:肾上腺素信号通路在心血管疾病的调控。近年来在探索肾上腺素信号通路与胰岛素的相互作用参与糖尿病心脏功能不全的发病机制取得一系列成果,在Circulation、Diabetes、J Bio Chem等国际知名期刊发表多篇论文。主持及参与多项国家自然科学基金、省厅项目等部委课题。目前课题组主要开展肾上腺素受体在糖尿病心血管等并发症的发病机制及药物治疗相关研究。

E-mail:fuqin@mails.tjmu.edu.cn

目前主持的主要科研项目:

1.2018.1-2021.12,国家自然科学基金面上项目,PDE4调控的心脏成纤维细胞miR-1应答高胰岛素血症在糖尿病心肌纤维化中的作用机制及干预研究

2.2018.1-2021.12,国家自然科学基金海外及港澳学者合作研究基金延续项目,β2肾上腺素受体依赖性的胰岛素促心肌GLUT4转运对β受体阻滞剂抗糖尿病心力衰竭疗效的影响

3. 2015.1-2018.12,国家自然科学基金面上项目,β2肾上腺素受体依赖性的胰岛素诱导的PDE4在糖尿病心功能不全中的作用

代表性学术论文:

1.Fu Q#, Hu Y, Wang Q, Liu Y, Li N, Xu B, Kim S, Chiamvimonvat N, Xiang YK#. High-fat diet induces protein kinase A and G-protein receptor kinase phosphorylation of β(2) -adrenergic receptor and impairs cardiac adrenergic reserve in animal hearts.J Physiol.2017 Mar 15;595 (6):1973-1986. (*共同通讯作者)

2.Fu Q#, Wang Q#, Xiang YK#. Insulin and β Adrenergic Receptor Signaling: Crosstalk in Heart.Trends Endocrinol Metab. 2017 Jun;28(6):416-427 (*共同通讯作者)

3.Wang Q*, Liu Y*,Fu Q*, Xu B, Zhang Y, Kim S, Tan R, Barbagallo F, West T, Anderson E, Wei W, Abel ED, Xiang YK. Inhibiting Insulin-Mediated β2-Adrenergic Receptor Activation Prevents Diabetes-Associated Cardiac Dysfunction.Circulation. 2017 Jan 3;135(1):73-88. (*共同第一作者)

4.Fu Q, Xu B, Liu Y, Parikh D, Li J, Li Y, Zhang Y, Riehle C, Zhu Y, Rawlings T, Shi Q, Clark RB, Chen X, Abel ED, Xiang YK. Insulin inhibits cardiac contractility by inducing a Gi-biased β2 adrenergic signaling in hearts.Diabetes.2014 Aug;63(8):2676-89

5.Fu Q*, Xu B, Parikh D, Cervantes D, Xiang YK. Insulin induces IRS2-dependent and GRK2-mediated β2AR internalization to attenuate βAR signaling in cardiomyocytes.Cell Signal.2015 Mar;27(3):707-15 (*通讯作者)

6.Fu Q#*,Kim S#, Soto D, De Arcangelis V, Dipilato L, Liu S, Xu B, Zhang J, Shi Q, Xiang YK*. A long-lasting β1 adrenergic receptor stimulation of cAMP/PKA signals in cardiac myocytes.J Biol Chem.2014 May 23;289(21):14771-81 (*共同通讯作者)

7.Fu Q, Chen X, Xiang YK. Compartmentalization of β-adrenergic signals in cardiomyocytes.Trends Cardiovasc Med.2013 Oct;23(7):250-6

8.Zhang Q, Xiang J, Wang X, Liu H, Hu B, Feng M,Fu Q*. Beta(2)-adrenoceptor agonist clenbuterol reduces infarct size and myocardial apoptosis after myocardial ischaemia/reperfusion in anaesthetized rats.Br J Pharmacol.2010 160(6):1561-72. (*通讯作者)

9.Liu P, Xiang JZ, Zhao L, Yang L, Hu BR,Fu Q*. Effect of beta2-adrenergic agonist clenbuterol on ischemia/reperfusion injury in isolated rat hearts and cardiomyocyte apoptosis induced by hydrogen peroxide.Acta Pharmacol Sin.2008 29(6):661-9. (*通讯作者)

10.Fu Q,Xiang YK. Trafficking of β-Adrenergic Receptors: implications in intracellular receptor signaling.Prog Mol Biol Transl Sci.2015;132:151-88

11.Barbagallo F, Xu B, Reddy GR, West T, Wang Q,Fu Q, Li M, Shi Q, Ginsburg KS, Ferrier W, Isidori AM, Naro F, Patel HH, Bossuyt J, Bers D, Xiang YK. Genetically Encoded Biosensors Reveal PKA Hyperphosphorylation on the Myofilaments in Rabbit Heart Failure.Circ Res.2016 Sep 30;119 (8):931-43

12.Shi Q, Li M, Mika D,Fu Q, Kim S, Phan J, Shen A, Vandecasteele G, Xiang YK. Heterologous desensitization of cardiac β-adrenergic signal via hormone-induced βAR/arrestin/PDE4 complexes.Cardiovasc Res.2017 May 1;113(6):656-670.

13.Yang X, Wang T, Lin X, Yue X, Wang Q, Wang G,Fu Q, Ai X, Chiang DY, Miyake CY, Wehrens XH, Chang J. Genetic deletion of Rnd3/RhoE results in mouse heart calcium leakage through upregulation of proteinkinase A signaling.Circ Res.2015 Jan 2;116(1):e1-e10

14.Wang D,Fu Q, Zhou Y, Xu B, Shi Q, Igwe B, Matt L, Hell JW, Wisely EV, Oddo S,Xiang YK. β2 adrenergic receptor, protein kinase A (PKA) and c-Jun N-terminal kinase (JNK) signaling pathways mediate tau pathology in Alzheimer disease models.J Biol Chem.2013 Apr 12;288(15):10298-307.

15.Zhang X, Szeto C, Gao E, Tang M, Jin J,Fu Q, Makarewich C, Ai X, Li Y, Tang A, Wang J, Gao H, Wang F, Ge XJ, Kunapuli SP, Zhou L, Zeng C, Xiang KY, Chen X. Cardiotoxic and cardioprotective features of chronic β-adrenergic signaling.Circ Res.2013 Feb 1;112 (3):498-509.

16.Liu R, Wang D, Shi Q,Fu Q, Hizon S, Xiang YK. Palmitoylation Regulates Intracellular Trafficking of β(2) Adrenergic Receptor/Arrestin/Phosphodiesterase 4D Complexes in Cardiomyocytes.PLos One.2012; 7(8): e42658

17.Liu S, Li Y, Kim S,Fu Q, Parikh D, Sridhar B, Shi Q, Zhang X, Guan Y, Chen X, Xiang YK. Phosphodiesterases coordinate cAMP propagation induced by two stimulatory G protein-coupled receptors in hearts.Proc Natl Acad Sci U S A.2012 Apr 24;109(17):6578-83

18.Feng M, Xiang JZ, Ming ZY,Fu Q, Ma R, Zhang QF, Dun YY, Yang L, Liu H. Activation of epidermal growth factor receptor mediates reperfusion arrhythmias in anaesthetized rats.Cardiovasc Res.2012 Jan 1;93(1):60-8.

19.Li JJ, Tang Q, Li Y, Hu BR, Ming ZY,Fu Q*, Qian JQ, Xiang JZ*. Role of oxidative stress in the apoptosis of hepatocellular carcinoma induced by combination of arsenic trioxide and ascorbic acid.Acta Pharmacol Sin.2006 27(8):1078-84. (*共同通讯作者)

20.Fu Q, Hu BR, Han ZM, Xiang JZ.Effects of Clenbuterol on Phosphorylation of Phospholamban in Neonatal Rat CardiomyocytesJ Huazhong Univ Sci Technolog Med Sci.2007, 36( 4): 441-443

21.Pan LR, Tang Q,Fu Q, Hu BR, Xiang JZ, Qian JQ. Roles of nitric oxide in protective effect of berberine in ethanol-induced gastric ulcer mice.Acta Pharmacol Sin.2005 26(11):1334-8