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金满文

发布者: [发表时间]:2019-01-29 [来源]: [浏览次数]:



金满文

E-mail:tjmwjin@163.com

个人简介:教授,博士生导师。1976年作为最后一届工农兵学员进入武汉医学院临床医学系学习,1978年作为第一届硕士研究生进入武汉医学院药理教研室学习,1981年硕士毕业后留校任教。1985年赴联邦德国海德堡大学药理研究所进修,1988年获博士学位后回同济医科大学药理教研室任讲师,1992年破格晋升为药理学教授。1993年~1995年任药理学教研室副主任,1998年~1999年任药理教研室主任,2000年~2002年任药理系主任。曾任湖北省药理学会秘书长、副理事长兼秘书长。长期从事药理学的教学与科研工作,主持并参与多项国家自然科学基金项目、国家科技部科技攻关项目。

研究方向心血管和代谢性疾病及肿瘤靶点研究与药物开发

代表性论文*通讯作者):

  1. Chen KH, Xu XH, Sun HY, Du XL, Liu H, Yang L, Xiao GS, Wang Y, Jin MW*, Li GR*. Distinctive property and pharmacology of voltage-gated sodium current in rat atrial vs ventricular myocytes.Heart Rhythm, 2016, 13(3): 762-770

  2. Chen KH, Liu H, Yang L, Jin MW*, Li GR*. SKF-96365 strongly inhibits voltage-gated sodium current in rat ventricular myocytes.Pflugers Arch, 2015, 467(6): 1227-1236

  3. Chen KH, Xu XH, Liu Y, Hu Y, Jin MW*, Li GR*. TRPM7 channels regulate proliferation and adipogenesis in 3T3-L1 preadipocytes.J Cell Physiol, 2014, 29(1): 60-67

  4. Xin X, Li XH, Wu JZ, Chen KH, Liu Y, Nie CJ, Hu Y, Jin MW*. Pentamethylquercetin ameliorates fibrosis in diabetic Goto-Kakizaki rat kidneys and mesangial cells with suppression of TGF-β/Smads signaling.Eur J Pharmacol, 2013, 713(1-3): 6-15

  5. Xu XH, Sun HY, Zhang YH, Wu W, Chen KH, Liu Y, Deng CY, Yu XY, Jin MW*, Li GR*. Allitridi inhibits multiple cardiac potassium channels expressed in HEK 293 cells.PLoS One, 2012, 7(12): e51550

  6. Li XH, Xin X, Wang Y, Wu JZ, Jin ZD, Ma LN, Nie CJ, Xiao X, Hu Y, Jin MW*, Pentamethylquercetin Protects Against Diabetes-Related Cognitive Deficits in Diabetic Goto-Kakizaki Rats.J Alzheimers Dis, 2013, 34(3): 755-767

  7. Liu Y, Xu XH, Liu Z, Du XL, Chen KH, Xin X, Jin ZD, Shen JZ, Hu Y, Li GR, Jin MW*, Effects of the natural flavone trimethylapigenin on cardiac potassium currents.Biochem Pharmacol, 2012, 84(4): 498-506

  8. Shen JZ, Ma LN, Han Y, Liu JX, Yang WQ, Chen L, Liu Y, Hu Y, Jin MW*, Pentamethylquercetin generates beneficial effects in monosodium glutamate-induced obese mice and C2C12 myotubes by activating AMP-activated protein kinase.Diabetologia, 2012, 55(6): 1836-1846

  9. He T, Chen L, Chen Y, Han Y, Yang WQ, Jin MW*, In Vivo and In Vitro Protective Effects of Pentamethylquercetin on Cardiac Hypertrophy.Cardiovasc Drugs Ther, 2012, 26(2): 109-120

  10. Zhang XH, Zhang YY, Sun HY, Jin MW*, Li GR*, Functional ion channels and cell proliferation in 3T3-L1 preadipocytes.J Cell Physiol, 2012, 227(5): 1972–1979

  11. Chen L, He T, Han Y, Sheng JZ, Jin S, Jin MW*, Pentamethylquercetin Improves Adiponectin Expression in Differentiated 3T3-L1 Cells via a Mechanism that Implicates PPARγ together with TNF-α and IL-6.Molecules, 2011, 16(7): 5754-5768

  12. Zhang XH, Jin MW*, Sun HY, Zhang S, Li GR*, The calmodulin inhibitor N-(6-aminohexyl)-5-chloro-1-naphthalene sulphonamide directly blocks human ether à-go-go-related gene potassium channels stably expressed in human embryonic kidney 293 cells.Br J Pharmacol, 2010, 161(4): 872-884

  13. Han Y, Chen JD, Liu ZM, Zhou Y, Xia JH, Du XL, Jin MW*, Functional ion channels in mouse cardiac c-kit+cells.Am J Physiol Cell Physiol, 2010, 298(5): 1109-1117

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