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吴鹏飞

发布者: [发表时间]:2018-04-17 [来源]: [浏览次数]:

46D2A

吴鹏飞,博士,华中科技大学同济医学院药理系副教授,研究生导师。2007年毕业于华中科技大学同济医学院药学院生物药学(国家生命科学技术基地班)专业,获理学学士学位。2012年6月毕业于华中科技大学同济医学院基础医学院药理学专业,获医学博士学位。

获第二十一届“中国药理学会施维雅青年药理学家奖”、第十六届湖北省自然科学优秀论文奖一等奖、教育部“博士研究生学术新人奖”、裘法祖医学奖、华中科技大学教师教学竞赛二等奖、华中科技大学研究生“科技十佳”等奖励。主要研究方向:氧化还原修饰&内源性化学修饰和神经精神疾病发病机制;基于老药新用途和新机制的转化医学研究。2010年起以第一作者、共同第一作者或通讯作者在国际著名期刊如Biological PsychiatryAging CellThe Journal of NeuroscienceAntioxidants&Redox SignalingMolecular PharmacologyBritish Journal of Pharmacology等上发表B类以上SCI论文20余篇,累积影响因子超过120。获得国家发明专利授权4项,申请3项。作为负责人主持国家自然科学基金2项,华中科技大学创新研究基金重点项目、转化医学专项各1项。并参与抗血管性痴呆一类新药候选药物ST09、药妆类产品"营养护发喷雾"、劲牌虫草粉等多个产品研发项目。联系方式:QQ:398173358 邮箱 wupengfeipharm@foxmail.com wupengfeihust@sina.com

研究方向:神经精神药理学,新药开发及评价。

具体研究领域为:基于氧化还原修饰&内源性化学修饰的神经精神疾病治疗靶点研究;基于老药新用途和新机制的转化医学和药物开发研究。

主要科研项目:

1 No.81773712 转运蛋白SVCT2依赖的维生素C稳态调控机制异常在抑郁症发病中的作用及药物干预研究,国家自然科学基金面上项目,主持

2 No.81302754 蛋氨酸亚砜还原酶A负性调控ROS/MAPKs/NF-kB信号通路在小胶质细胞炎性活化中的作用及机制,国家自然科学基金青年科学基金项目,主持

3 华中科技大学创新研究基金重点项目《基于蛋白质去棕榈酰化机制的AMPA受体增强剂开发及其抗抑郁效应研究》,主持

4 华中科技大学创新研究基金(转化医学专项)《氧化应激生物标记物蛋白质蛋氨酸亚砜的快速检测试剂盒》,主持

5 No.81473198自噬诱导的伏隔核区GABAA受体功能异常在可卡因成瘾中的作用,国家自然科学基金面上项目,参与(排名第二)

6 No.81473199小胶质细胞特有质子通道Hv1调节氧化应激在可卡因成瘾中的作用及机制研究,国家自然科学基金面上项目,参与(排名第二)

重要学术论文:

Shen ZC,Wu PF (co-first author,吴鹏飞),Wang F, Deng Q, Nie TL, Zhang SQ, Zheng HL, Liu WH, Lu JJ, Gao SQ, Yao XP, Long LH, Hu ZL, Chen JG. Gephyrin Palmitoylation in Basolateral Amygdala Mediates the Anxiolytic Action of Benzodiazepine.Biological Psychiatry, In press, accepted manuscript, /doi.org/10.1016/j.biopsych.2018.09.024

Luo H,Wu PF (co-first author,吴鹏飞), Han QQ, Cao Y, Deng SL, Wang J, Deng Q, Wang F, Chen JG. Reactive Sulfur Species Emerge as Gliotransmitters to Support Memory via Sulfuration-Dependent Gating of NR2A-Containing N-Methyl-d-Aspartate Subtype Glutamate Receptor Function.Antioxid Redox Signal.2018 Oct 12. doi: 10.1089/ars. 2018.7503.

Xia ZX, Shen ZC, Zhang SQ, Wang J, Nie TL, Deng Q, Chen JG, Wang F,Wu PF(吴鹏飞,通讯作者).De-palmitoylation by N-(tert-Butyl) hydroxylamine inhibits AMPAR-mediated synaptic transmission via affecting receptor distribution in postsynaptic densities.CNS Neurosci Ther. 2018 Jun 17. doi: 10.1111/cns.12996.

Han QQ, Shen TT, Wang F,Wu PF(吴鹏飞,通讯作者), Chen JG.Preventive and Therapeutic Potential of Vitamin C in Mental Disorders.Curr Med Sci2018; 38(1):1-10.

Li YL,Wu PF (co-first author,吴鹏飞), Chen JG, Wang S, Han QQ, Li D, Wang W, Guan XL, Li D, Long LH, Huang JG, Wang F. Activity-Dependent Sulfhydration Signal Controls N-Methyl-D-Aspartate Subtype Glutamate Receptor-Dependent Synaptic Plasticity via Increasing d-Serine Availability.Antioxid Redox Signal2017; 27(7):398-414.(封面文章)

Guan XL,Wu PF (co-first author,吴鹏飞), Wang S, Zhang JJ, Shen ZC, Luo H, Chen H, Long LH, Chen JG, Wang F.Dimethyl sulfide protects against oxidative stress and extends lifespan via a methionine sulfoxide reductase A-dependent catalytic mechanism.Aging Cell. 2017; 16(2): 226-236.

Fan H,Wu PF (co-first author,吴鹏飞), Zhang L, Hu ZL, Wang W, Guan XL, Luo H, Ni M, Yang JW, Li MX, Chen JG*, Wang F*. Methionine sulfoxide reductase A negatively controls microglia-mediated neuroinflammation via inhibiting ROS/MAPKs/NF-κB signaling pathways through a catalytic antioxidant function.Antioxid Redox Signal. 2015; 22(10):832-47.

Lu HF,Wu PF (co-first author,吴鹏飞), Yang YJ, Xiao W, Fan J, Liu J, Li YL, Luo Y, Hu ZL, Jin Y, Wang F*, Chen JG*. Interactions between N-ethylmaleimide- sensitive factor and GluR2 in the nucleus accumbens contribute to the expression of locomotor sensitization to cocaine.J Neurosci. 2014; 34(10):3493-508.

Yang YJ,Wu PF (co-first author,吴鹏飞), Long LH, Yu DF, Wu WN, Hu ZL, Fu H, Xie N, Jin Y, Ni L, Wang JZ, Wang F*, Chen JG*. Reversal of aging- associated hippocampal synaptic plasticity deficits by reductants via regulation of thiol redox and NMDA receptor function.Aging Cell. 2010; 9(5):709-21.

Li YL, Zhou J, Zhang H, Luo Y, Long LH, Hu ZL, Chen JG, Wang F,Wu PF(吴鹏飞,通讯作者). Hydrogen Sulfide Promotes Surface Insertion of Hippocampal AMPA Receptor GluR1 Subunit via Phosphorylating at Serine-831/Serine-845 Sites Through a Sulfhydration-Dependent Mechanism.CNS Neurosci Ther. 2016, 22(9):789-98.

Wang X, Cao H, Guan XL, Long LH, Hu ZL, Ni L, Wang F, Chen JG,Wu PF(吴鹏飞,通讯作者). Sulfite triggers sustained calcium overload in cultured cortical neurons via a redox-dependent mechanism.Toxicol Lett.2016, 258:237-48.

Han J, Zhang H, Wang S, Zhou J, Luo Y, Long LH, Hu ZL, Wang F, Chen JG,Wu PF (吴鹏飞,通讯作者). Potentiation of Surface Stability of AMPA Receptors by Sulfhydryl Compounds: A Redox-Independent Effect by Disrupting Palmitoylation.Neurochem Res. 2016, 41(11):2890-2903.

Ma J, Long LH, Hu ZL, Zhang H, Han J, Ni L, Wang F, Chen JG,Wu PF(吴鹏飞,通讯作者). Activation of D1-like receptor-dependent phosphatidylinositol signal pathway by SKF83959 inhibits voltage-gated sodium channels in cultured striatal neurons.Brain Res. 2015; 1615:71-9.

Wu PF (吴鹏飞), Xie N, Zhang JJ, Guan XL, Zhou J, Long LH, Li YL, Xiong QJ, Zeng JH, Wang F, Chen JG*. Resveratrol preconditioning increases methionine sulfoxide reductases A expression and enhances resistance of human neuroblastoma cells to neurotoxins. J Nutr Biochem. 2013; 24(6):1070-7.

Wu PF (吴鹏飞), Zhang Z, Guan XL, Li YL, Zeng JH, Zhang JJ, Long LH, Hu ZL, Wang F, Chen JG. A specific and rapid colorimetric method to monitor the activity of methionine sulfoxide reductase A.Enzyme Microb Technol. 2013; 53(6-7):391-7.

Wu PF (吴鹏飞), Long LH, Zeng JH, Guan XL, Zhou J, Jin Y, Ni L, Wang F, Chen JG, Xie N. Protection of L-methionine against H₂O₂-induced oxidative damage in mitochondria.Food Chem Toxicol. 2012 , 50(8):2729-35.

Wu WN,Wu PF (co-first author,吴鹏飞), Zhou J, Guan XL, Zhang Z, Yang YJ, Long LH, Xie N, Chen JG, Wang F*.Orexin-A Activates Hypothalamic AMP-Activated Protein Kinase Signaling through a Ca2+ - Dependent Mechanism Involving Voltage-Gated L-Type Calcium Channel.Mol Pharmacol.2013; 84(6):876-87.

Wu WN,Wu PF (co-first author,吴鹏飞),Chen XL, Zhang Z, Gu J, Yang YJ, Xiong QJ, Ni L, Wang F, Chen JG. Sinomenine protects against ischaemic brain injury: involvement of co-inhibition of acid-sensing ion channel 1a and L-type calcium channels.Br J Pharmacol. 2011; 164(5):1445-59.

Long LH,Wu PF (co-first author,吴鹏飞), Guan XL, Zhang JQ, Jin Y, Zhang Z, Wang Y, Li YY, Chen JG, Wang F. Determination of Protein-bound Methionine Oxidation in the Hippocampus of Adult and Old Rats by LC-ESI-ITMS Method after Microwave-assisted Proteolysis.Anal Bioanal Chem. 2011; 399(6):2267-74.

发明专利:

1.一种蛋氨酸亚砜还原酶活性的检测方法及药物筛选试剂盒;授权专利号:ZL 2009 1 0273177.8,排名第二;

2.重组Trx-TAT-hMsrA融合蛋白及其在神经细胞保护方面的应用;授权专利号:ZL 2010 1 0197729.4,排名第三(“独占许可”形式转让);

3.含巯基他克林衍生物及其制备方法和应用;授权专利号:ZL 2011 1 0216334. 9,排名第六;

4.氨基噻唑衍生物及制备方法和医药用途;授权专利号:ZL 2011 1 0216344.2,排名第七

5.一种快速消除口臭的生物技术口气清新剂及其医药用途;公开号: CN106806886A,排名第二。

6.一种防治酒精中毒性精神障碍的功能性食品和药品及其制法;申请号:201710918907.X,排名第二。

7. 一种用于防治创伤后应激综合征的药物和功能性食品;申请号:201711235555.4,排名第二。