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徐戎

发布者: [发表时间]:2018-04-17 [来源]: [浏览次数]:

13F4B

徐戎,女,博士,教授,美国康奈尔医学院附属Methodist医院研究所博士后。

研究方向:肿瘤药理学;纳米医学;临床药理学;新药研究与评价

主要研究工作:

主要应用先进的纳米技术构建新型抗肿瘤纳米药物,开展抗肿瘤药物药效学、作用机制研究。近年来以纳米多孔硅颗粒为平台,携载小分子药物、核酸药物等,构建可注射纳米颗粒生成器、多级载药系统以调控DNA损伤修复、肿瘤干细胞、肿瘤免疫等信号通路,探索治疗转移、耐药等难治性恶性肿瘤的新策略。并参与多项创新药物临床前及临床Ⅰ期药代动力学试验研究。多项研究成果发表在Nature Biotechnology、ACS Nano、Small、Nanoscale、J EXP CLIN CANC RES等高水平SCI杂志上。发表文章中单篇影响因子最高43.113分。获华中科技大学十佳优秀青年教工、华中科技大学十大科技新星、华中科技大学高水平科技论文奖、华中科技大学教学质量优秀奖、华中科技大学青年教师教学竞赛奖、美国NCI德州抗癌药物中心优秀博士后奖等奖励。其创新性研究成果被《Science》、《JAMA》、《Molecular Therapy》等杂志,以及美国国立卫生研究院、美国国家癌症研究所、华中科技大学首页等媒体作为最新研究亮点进行推荐。近年来负责承担了国家自然科学基金、湖北省自然科学基金杰出青年基金项目、湖北省卫生和计划生育委员会青年人才项目、武汉市科技计划项目、华中科技大学院系自主创新研究基金重点项目、科技部国际科技合作计划子课题等科研课题。任中国药理学会临床药理专业委员会委员、中国药理学会肿瘤药理专业委员会委员、中国抗癌协会抗癌药物专业委员会委员、湖北省药理学会理事和华中科技大学药物临床试验伦理委员会办公室主任。

发表的期刊论文:

1.Tang Y*, Li Y*,Xu R*, Li S, Hu H, Xiao C, Wu H, Zhu L, Ming J, Chu Z, Xu H, Yang X, Li Z.Self-assembly of folic acid dextran conjugates for cancer chemotherapy.Nanoscale. 2018 Sep 7. doi: 10.1039/c8nr04657c.(IF 7.233)

2.Cao S, Wang Z, Gao X, He W, Cai Y, Chen H,Xu R.FOXC1 induces cancer stem cell-like properties through upregulation of beta-catenin in NSCLC.J Exp Clin Cancer Res. 2018 Sep 6;37(1):220. doi: 10.1186/s13046-018-0894-0(IF 6.217)

3.Mai J, Li X, Zhang G, Huang Y,Xu R, Shen Q, Lokesh GL, Thiviyanathan V, Chen L, Liu H, Zu Y, Ma X, Volk DE, Gorenstein DG, Ferrari M, Shen H.DNA Thioaptamer with homing specificity to lymphoma bone marrow involvement. Mol Pharm. 2018 May 7;15(5):1814-1825.(IF 4.556)

4.Liu H, Mai J, Shen J, Wolfram J, Li Z, Zhang G,Xu R, Li Y, Mu C, Zu Y, Li X, Lokesh GL, Thiviyanathan V, Volk DE, Gorenstein DG, Ferrari M, Hu Z, Shen H.A novel DNA aptamer for dual targeting of polymorphonuclear myeloid-derived suppressor cells and tumor cells.Theranostics. 2018 Jan 1;8(1):31-44. doi: 10.7150/thno.21342. eCollection 2018.(IF 8.537)

5.Mei C, Zhou S, Zhu L, Ming J, Zeng F,Xu R.Antitumor effects of laminaria extract fucoxanthin on lung cancer.Mar Drugs. 2017 Feb 15;15(2). pii: E39. doi: 10.3390/md15020039.(IF 4.379)

6.Wang Z, Kerketta R, Chuang YL, Dogra P, Butner JD, Brocato TA, Day A,Xu R, Shen H, Simbawa E, Al-Fhaid AS, Mahmoud SR, Curley SA, Ferrari M, Koay EJ, Cristini V.Theory and experimental validation of a spatio-temporal model of chemotherapy transport to enhance tumor cell kill.PLoS Comput Biol. 2016 Jun 10;12(6):e1004969.(IF 3.955)

7.Xu R*, Zhang G*, Mai J*, Deng X*, Segura-Ibarra V, Wu S, Shen J, Liu H, Hu Z, Chen L, Huang Y, Koay E, Huang Y, Liu J, Ensor JE, Blanco E, Liu X, Ferrari M, Shen H.An injectable nanoparticle generator enhances delivery of cancer therapeutics.Nat Biotechnol. 2016 Apr;34(4):414-8.(IF 43.113)

8.Zhu Y, He W, Gao X, Li B, Mei C,Xu R, Chen H.Resveratrol overcomes gefitinib resistance by increasing the intracellular gefitinib concentration and triggering apoptosis, autophagy and senescence in PC9/G NSCLC cells.Sci Rep. 2015 Dec 4;5:17730. doi: 10.1038/srep17730.(IF 4.122)

9.Mei C, Li B, Yin Q, Jin J, Xiong T, He W, Gao X,Xu R, Zhou P, Zheng H, Chen H. Liquid chromatography-tandem mass spectrometry for the quantification of flurbiprofen in human plasma and its application in a study of bioequivalence.J Chromatogr B Analyt Technol Biomed Life Sci. 2015 Jul 1;993-994:69-74.(IF 2.603)

10.Xia X, Mai J,Xu R, Perez JE, Guevara ML, Shen Q, Mu C, Tung HY, Corry DB, Evans SE, Liu X, Ferrari M, Zhang Z, Li XC, Wang RF, Shen H.Porous silicon microparticle potentiates anti-tumor immunity by enhancing cross-presentation and inducing type I interferon response.Cell Rep. 2015 May 12;11(6):957-66.(IF 8.282)

11.Gizzatov A, Stigliano C, Ananta JS, Sethi R,Xu R,Guven A, Ramirez M, Shen H, Sood A, Ferrari M, Wilson LJ, Liu X, Decuzzi P.Geometrical confinement of Gd(DOTA) molecules within mesoporous silicon nanoconstructs for MR imaging of cancer.Cancer Lett. 2014 Sep 28;352(1):97-101.(IF6.491)

12.Mai J, Huang Y, Mu C, Zhang G,Xu R, Guo X, Xia X, Volk DE, Lokesh GL, Thiviyanathan V, Gorenstein DG, Liu X, Ferrari M, Shen H.Bone marrow endothelium-targeted therapeutics for metastatic breast cancer.J Control Release. 2014 Aug 10;187:22-9.(IF 7.877)

13.Zhang M,Xu R, Xia X, Yang Y, Gu J, Qin G, Liu X, Ferrari M, Shen H.Polycation-functionalized nanoporous silicon particles for gene silencing on breast cancer cells.Biomaterials. 2014 Jan;35(1):423-31.(IF 8.806)

14.Shen J*,Xu R*, Mai J*, Kim HC, Guo X, Qin G, Yang Y, Wolfram J, Mu C, Xia X, Gu J, Liu X, Mao ZW, Ferrari M, Shen H.High capacity nanoporous silicon carrier for systemic delivery of gene silencing therapeutics.ACS Nano. 2013 Nov 26;7(11):9867-80.(IF 13.942)

15.Fan J, Huang Y, Finoulst I, Wu HJ, Deng Z,Xu R, Xia X, Ferrari M, Shen H, Hu Y.Serum peptidomic biomarkers for pulmonary metastatic melanoma identified by means of a nanopore-based assay.Cancer Lett. 2013 Jul 1;334(2):202-10.(IF 6.491)

16.Xu R, Huang Y, Mai J, Zhang G, Guo X, Xia X, Koay EJ, Qin G, Erm DR, Li Q, Liu X, Ferrari M, Shen H.Multistage vectored siRNA targeting ataxia-telangiectasia mutated for breast cancer therapy.Small. 2013 May 27;9(9-10):1799-808.(IF 9.598)

17.Shen H, Rodriguez-Aguayo C,Xu R, Gonzalez-Villasana V, Mai J, Huang Y, Zhang G, Guo X, Bai L, Qin G, Deng X, Li Q, Erm DR, Aslan B, Liu X, Sakamoto J, Chavez-Reyes A, Han HD, Sood AK, Ferrari M, Lopez-Berestein G.Enhancing chemotherapy response with sustained EphA2 silencing using multistage vector delivery.Clin Cancer Res. 2013 Apr 1;19(7):1806-15.(IF 10.199)

18.Xu R, Yang XY, Yang DF, Zou CY, Gong PL, Zeng FD.Phase I evaluation of the safety and pharmacokinetics of a single-dose intravenous injection of a murine monoclonal antibody against Hantaan virus in healthy volunteers. Antimicrob Agents Chemother. 2009 Dec;53(12):5055-9.(IF 4.415)

19.Zhao L, Yang X,Xu R, Wu J, Gu S, Zhang L, Gong P, Chen H, Zeng F.Safety, tolerability and pharmacokinetics of phenoprolamine hydrochloride floating sustained-release tablets in healthy Chinese subjects.Int J Pharm. 2009 Jul 30;377(1-2):99-104.(IF 3.994)

20.Zhao L, Hu J, Chang Q, Ke Q,Xu R, Gu S, Chen H, Zeng F.A simple and sensitive HPLC method for quantitation of low phenoprolamine hydrochloride concentrations in human plasma and its pharmacokinetic application.Biomed Chromatogr. 2008 Mar;22(3):333-8.(IF 1.729)

联系方式:

电话:027-83691785 邮箱:rongxu@hust.edu.cn

武汉市航空路13号同济医学院基础医学院2号楼15楼药理学系