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胡壮丽

发布者: [发表时间]:2018-04-17 [来源]: [浏览次数]:


1D052

 

胡壮丽

Email:zlhu916@hotmail.com

研究方向:神经药理

 

承担的主要科研项目:

1.国家自然科学基金青年基金 心肌酸敏感离子通道(ASICs):治疗心肌缺血的新靶点(No. 30901804);主持(已结题)

2.国家自然科学基金面上基金 酸敏感离子通道(ASICs):小胶质细胞炎症免疫反应的重要调节蛋白(No. 81173071);主持(已结题)

3.国家自然科学基金面上基金 小胶质细胞特有质子通道Hv1调节氧化应激在可卡因成瘾中的作用及机制研究(No. 81473199);主持

4.湖北省科技研究与开发计划项目 作用于多靶点神经保护药物的合作研发(2011BFA006);主持(已结题)

5.国家重点基础研究发展计划 潜在抑郁风险评估相关的生物信息;2014.1-2018.8;73万;参与(排名第二)

6.湖北省科技厅群体项目 抑郁症发病机制及干预策略研究创新群体;2015.1-2017.12;参与(排名第三)

 

代表性论文:

①.Ming Ni#, Jin-Gang He#, Hai-Yun Zhou, Xiao-Jia Lu, Yuan-Lang Hu, Li Mao, Fang Wang, Jian-Guo Chen,Zhuang-Li Hu*. Pannexin-1 channel dysfunction in the medial prefrontal cortex mediates depressive-like behaviors induced by chronic social defeat stress and administration of mefloquine in mice. Neuropharmacology, 2017 Dec 5.

②.Xiao-Yi Hou,Zhuang-Li Hu(并列第一作者), Deng-Zheng Zhang, Wei Lu, Jun Zhou, Pei-Fei Wu, Xin-Lei Guan, Qian-Qian Han, Si-Long Deng, Hai Zhang, Jian-Guo Chen*and Fang Wang*. Rapid Antidepressant Effect of Hydrogen Sulfide: Evidence for Activation of mTORC1-TrkB-AMPA Receptor Pathways.Antioxid Redox Signal.2017 Feb 3.

③.Yuan-Lang Hu#,Xue Mi#,Chao Huang,Hui-Fang Wang,Jian-Ren Song,Qing Shu,Lan Ni,Jian-Guo Chen,Fang Wang,Zhuang-Li Hu*.Multiple H+sensors mediate the extracellular acidification-induced [Ca2+]i elevation in cultured rat ventricular cardiomyocytes.Sci Rep.2017 Mar 23;7:44951.

④.Hui Fu#, Peng Fang#, Hai-Yun Zhou, Jun Zhou, Xiao-Wei Yu, Ming Ni, Jie-Yan Zheng, You Jin, Jian-Guo Chen, Fang Wang andZhuang-Li Hu*. Acid-sensing ion channels in trigeminal ganglion neurons innervating the orofacial region contribute to orofacial inflammatory pain.Clin Exp Pharmacol Physiol.2016 Feb;43(2):193-202.

⑤.Xiao-Wei Yu,Zhuang-Li Hu(并列第一作者), Ming Ni, Peng Fang, Pei-Wei Zhang, Qing Shu, Hua Fan, Hai-Yun Zhou, Lan Ni, Ling-Qiang Zhu, Jian-Guo Chen*and Fang Wang*.Acid-sensing ion channels promote the inflammation and migration of cultured rat microglia.Glia.2015 Mar;63(3):483-96.

⑥.Qiu-Ju Xiong,Zhuang-Li Hu(并列第一作者), Peng-Fei Wu, Lan Ni, Zhi-Fang Deng, Wen-Ning Wu, Jian-Guo Chen, Fang Wang*.Acid-sensing ion channels contribute to the increase in vesicular release from SH-SY5Y cells stimulated by extracellular protons.Am J Physiol Cell Physiol.2012 Aug; 303(4):C376-84.

⑦.Rui-Li Liu, Qiu-Ju Xiong, Qing Shu, Wen-Ning Wu, Jin Cheng, Hui Fu,FangWang, Jian-Guo Chen,Zhuang-Li Hu*.Hyperoside protects cortical neurons from oxygen-glucose deprivation-reperfusion induced injury via nitric oxide signal pathway.Brain Res.2012 Aug 21;1469:164-73.

⑧.Zhuang-Li Hu,Chao Huang, Hui Fu,You Jin,Wen-Ning Wu, Qiu-Ju Xiong,Na Xie, Li-Hong Long,Jian-Guo ChenandFang Wang*.PICK1disruptionattenuates bothfunctionsof ASICsand regulations ofPKCon ASICs.Am J Physiol Cell Physiol.2010 Dec;299(6):C1355-62.

⑨.Chao Huang,Zhuang-Li Hu(并列第一作者), Wen-ning Wu, Dan-Fang Yu, Qiu-Ju Xiong, Jian-Ren Song, Qing Shu, Hui Fu, Fang Wang*and Jian-Guo Chen*.Existenceand distinction of acid-evoked currents inrat astrocytes.Glia. 2010 Sep;58(12):1415-24.

⑩.Zhuangli Hu,Juan Chen, Qin Wei, and Yong Xia*. Bidirectional Actions of Hydrogen Peroxide on Endothelial Nitric Oxide Synthase Phosphorylation and Function: co-commitment and interplay of Akt and AMPK.J. Biol. Chem.2008 Sep 12; 283(37): 25256-25263.