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胡壮丽

发布者: [发表时间]:2020-08-09 [来源]: [浏览次数]:

 

1D052

胡壮丽,博士,华中科技大学同济医学院药理学系教授,武汉市药理学会理事。1999年毕业于原同济医科大学临床医疗专业,获学士学位。2004-2005在美国俄亥俄州立大学学术交流一年,2008年获得华中科技大学博士学位。主要从事离子通道、神经胶质细胞与情感障碍性疾病的研究。作为负责人主持国家自然科学基金四项,湖北省科技研究与开发计划项目一项,并参与多项国家级和省级研究项目。以第一和通讯作者在Biol PsychiatryAntioxid Redox SignalAddict Biol.Neuropharmacology,Glia,J. Biol. Chem,Am J Physiol Cell Physiol等杂志发表文章10余篇。

研究方向:神经药理

Email:zlhu916@hust.edu.cn

 

承担的主要科研项目:

1.国家自然科学基金青年基金心肌酸敏感离子通道(ASICs):治疗心肌缺血的新靶点(No. 30901804);主持

2.国家自然科学基金面上基金酸敏感离子通道(ASICs):小胶质细胞炎症免疫反应的重要调节蛋白(No. 81173071);主持

3.国家自然科学基金面上基金小胶质细胞特有质子通道Hv1调节氧化应激在可卡因成瘾中的作用及机制研究(No. 81473199);主持

4.国家自然科学基金面上基金GABAB2受体辅助蛋白KCTD12影响成年海马脑区神经发生在抑郁症中的作用及机制(No.81971266);主持

5.湖北省科技研究与开发计划项目作用于多靶点神经保护药物的合作研发(2011BFA006);主持

 

代表性论文:

  1. Hai-Yun Zhou, Jin-Gang He,Hu Zhuang-Li(并列第一作者), Shi-Ge Xue, Jun-Feng Xu, Qian-Qian Cui, Shuang-Qi Gao, Bin Zhou, Peng-Fei Wu, Li-Hong Long, Fang Wang, Jian-Guo Chen.A-Kinase Anchoring Protein 150-PKA Complex in the Basolateral Amygdala Contributes to Depressive-like Behaviors Induced by Chronic Restraint Stress.Biol Psychiatry. 2019 Jul 15; 86(2):131-142.

  2. Shuang-Qi Gao, Hai Zhang, Jin-Gang He, Hui-Ling Zheng, Pei-Wei Zhang, Jun-Feng Xu, Zu-Cheng Shen, Huan-Huan Zhao, Fang Wang,Zhuang-Li Hu*(并列通讯作者)andJian-Guo Chen*. Neuronal HMGB1 in nucleus accumbens regulates cocaine reward memory.Addict Biol.2019 May 6. doi: 10.1111/adb.12739. [Epub ahead of print]

  3. Ming Ni#, Jin-Gang He#, Hai-Yun Zhou, Xiao-Jia Lu, Yuan-Lang Hu, Li Mao, Fang Wang, Jian-Guo Chen,Zhuang-Li Hu*(通讯作者). Pannexin-1 channel dysfunction in the medial prefrontal cortex mediates depressive-like behaviors induced by chronic social defeat stress and administration of mefloquine in mice. Neuropharmacology, 2017 Dec 5.

  4. Xiao-Yi Hou,Zhuang-Li Hu(并列第一作者), Deng-Zheng Zhang, Wei Lu, Jun Zhou, Pei-Fei Wu, Xin-Lei Guan, Qian-Qian Han, Si-Long Deng, Hai Zhang, Jian-Guo Chen* and Fang Wang*. Rapid Antidepressant Effect of Hydrogen Sulfide: Evidence for Activation of mTORC1-TrkB-AMPA Receptor Pathways.Antioxid Redox Signal.2017 Feb 3.

  5. Yuan-Lang Hu#,Xue Mi#,Chao Huang,Hui-Fang Wang,Jian-Ren Song,Qing Shu,Lan Ni,Jian-Guo Chen,Fang Wang,Zhuang-Li Hu*(通讯作者).Multiple H+sensors mediate the extracellular acidification-induced [Ca2+]i elevation in cultured rat ventricular cardiomyocytes.Sci Rep.2017 Mar 23; 7: 44951.

  6. Hui Fu#, Peng Fang#, Hai-Yun Zhou, Jun Zhou, Xiao-Wei Yu, Ming Ni, Jie-Yan Zheng, You Jin, Jian-Guo Chen, Fang Wang andZhuang-Li Hu*(通讯作者). Acid-sensing ion channels in trigeminal ganglion neurons innervating the orofacial region contribute to orofacial inflammatory pain.Clin Exp Pharmacol Physiol.2016 Feb; 43(2):193-202.

  7. Xiao-Wei Yu,Zhuang-Li Hu(并列第一作者), Ming Ni, Peng Fang, Pei-Wei Zhang, Qing Shu, Hua Fan, Hai-Yun Zhou, Lan Ni, Ling-Qiang Zhu, Jian-Guo Chen* and Fang Wang*.Acid-sensing ion channels promote the inflammation and migration of cultured rat microglia.Glia.2015 Mar; 63(3):483-96.

  8. Qiu-Ju Xiong,Zhuang-Li Hu(并列第一作者), Peng-Fei Wu, Lan Ni, Zhi-Fang Deng, Wen-Ning Wu, Jian-Guo Chen, Fang Wang*.Acid-sensing ion channels contribute to the increase in vesicular release from SH-SY5Y cells stimulated by extracellular protons.Am J Physiol Cell Physiol.2012 Aug; 303(4):C376-84.

  9. Rui-Li Liu, Qiu-Ju Xiong, Qing Shu, Wen-Ning Wu, Jin Cheng, Hui Fu, Fang Wang, Jian-Guo Chen,Zhuang-Li Hu*.Hyperoside protects cortical neurons from oxygen-glucose deprivation-reperfusion induced injury via nitric oxide signal pathway.Brain Res.2012 Aug 21; 1469:164-73.

  10. Zhuang-Li Hu,Chao Huang, Hui Fu, You Jin, Wen-Ning Wu, Qiu-Ju Xiong, Na Xie, Li-Hong Long, Jian-Guo Chen and Fang Wang*.PICK1disruptionattenuates bothfunctions of ASICsand regulations ofPKC on ASICs.Am J Physiol Cell Physiol.2010 Dec; 299(6):C1355-62.

  11. Chao Huang,Zhuang-Li Hu(并列第一作者), Wen-ning Wu, Dan-Fang Yu, Qiu-Ju Xiong, Jian-Ren Song, Qing Shu, Hui Fu, Fang Wang*and Jian-Guo Chen*.Existenceand distinction of acid-evoked currents inrat astrocytes.Glia. 2010 Sep;58(12):1415-24.

  12. Zhuangli Hu,Juan Chen, Qin Wei, and Yong Xia*. Bidirectional Actions of Hydrogen Peroxide on Endothelial Nitric Oxide Synthase Phosphorylation and Function: co-commitment and interplay of Akt and AMPK.J. Biol. Chem.2008 Sep 12; 283(37): 25256-25263.