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徐旭林

发布者: [发表时间]:2018-04-17 [来源]: [浏览次数]:


4B0AB

 

徐旭林

E-mail:xulinxu@hust.edu.cn

个人简介:博士,副教授。2004年和2009年分别获华中科技大学同济医学院药理学硕士和博士学位, 2007年至2009年于美国弗吉尼亚州立大学进行学术交流。主要从事离子通道与神经精神疾病的研究,作为负责人主持国家自然科学基金项目1项,湖北省自然科学基金项目1项,华中科技大学校自主创新基金1项,并参与了多项国家自然基金课题。以第一和通讯作者在国际权威期刊NeuropharmacologyJournal of Neuroinflammation,Mol. Pharmacol.J Gen Physiol.,NeuroscienceBehav Brain Res等杂志发表论文多篇。

代表性论文:

1.Dan Zhao#,Xulin Xu#, Linna Pan, Wei Zhu, Xiaopei Fu, Lianjun Guo, Qing Lu and Jian Wang.Pharmacologic activation of cholinergic alpha7 nicotinic receptors mitigatesdepressive-like behavior in a mouse modelof chronic stress.Journal of Neuroinflammation (2017) 14:234.

2.Li C, Lu Q, Huang P, Fu T, Li C, Guo L,Xu X*.Activity-dependent downregulation of M-Type (Kv7) K(+) channels surface expression requires the activation of iGluRs/Ca(2+)/PKC signaling pathway in hippocampal neuron.Neuropharmacology. 2015 Aug;95:154-67.

3.Li C, Huang P, Lu Q, Zhou M, Guo L,Xu X*. KCNQ/Kv7 channel activator flupirtine protects against acute stress-induced impairments of spatial memory retrieval and hippocampal LTP in rats.Neuroscience. 2014 Nov 7;280:19-30.

4.Huang P, Li C, Fu T, Zhao D, Yi Z, Lu Q, Guo L,Xu X*. Flupirtine attenuates chronic restraint stress-induced cognitive deficits and hippocampal apoptosis in male mice. Behav Brain Res. 2015 Jul 15;288:1-10.

5.Li Y#,Xu XL#,Zhao D, Pan LN, Huang CW, Guo LJ, Lu Q, Wang J.TLR3 ligand Poly IC Attenuates Reactive Astrogliosis and Improves Recovery of Rats after Focal Cerebral Ischemia. CNS Neurosci Ther. 2015 Nov;21(11):905-13.

6.Xu X,Jiang M, Wang Y, Smith T, Baumgarten CM, Wood MA, Tseng GN.Long-term fish oil supplementation induces cardiac electrical remodeling by changing channel protein expression in the rabbit model.PLoS One. 2010 Apr 13;5(4):e10140.

7.Xu X,Recanatini M, Roberti M, Tseng GN. Probing the binding sites and mechanisms of action of two human ether-a-go-go-related gene channel activators, 1,3-bis-(2-hydroxy-5-trifluoromethyl-phenyl)-urea (NS1643) and 2-[2-(3,4-dichloro-phenyl)-2,3-dihydro-1H-isoindol-5-ylamino]-nicotinic acid (PD307243). Mol. Pharmacol. 2008 Jun; 73(6):1709-21.

8.Xu X,Jiang M, Hsu KL, Zhang M, Tseng GN. KCNQ1 and KCNE1 in the IKs channel complex make state-dependent contacts in their extracellular domains. J Gen Physiol. 2008 Jun; 131(6):589-603.

9. Jiang M,Xu X,Wang Y, Toyoda F, Liu XS, Zhang M, Robinson RB, Tseng GN.. Dynamic partnership between KCNQ1 and KCNE1 and influence on cardiac IKs current amplitude by KCNE2. J Biol Chem. 2009 ;284(24):16452-62.

承担的主要科研项目:

1.国家自然科学基金:KCNQ2 磷酸化水平调控海马神经元M(Kv7)通道活动依赖性转运(No:81001425),主持

2.湖北省自然科学基金项目:Kv7/M 通道在慢性应激所致学习记忆功能障碍中的作用及机制研究(No: 2014CFB142), 主持

3.华中科技大学校自主创新项目:Kv7通道在慢性应激抑郁模型小鼠海马神经髓鞘再生中的作用及调控机制研究(No: 2016YXMS190), 主持

4.国家自然科学基金:慢性脑低灌损伤HCN2对海马GABA抑制性中间神经元突触可塑性的修饰调节(No:81173038),主要成员

5.国家自然科学基金:Toll样受体介导的TRIF信号通路在脑缺血预适应炎症抑制中的作用研究(No:81001432),主要成员