付琴，博士，华中科技大学同济医学院药理学系教授、博士生导师。1998年同济医科大学临床医学系本科毕业留校任教至今。2006年获得华中科技大学同济医学院药理学博士学位。2003~2005年德国柏林Max-Delbrueck分子医学中心访问学者；2011-2014年美国伊利诺伊大学香槟分校和加州大学戴维斯分校博士后。
研究方向
研究领域为心血管药理学，主要研究方向为肾上腺素受体/磷酸二酯酶信号通路在心血管和代谢性疾病的调控和药物靶点研究。主持多项国家自然科学基金，以及海外合作项目。近年来在Circulation, Diabetes, Trends in Endocrinology and Metabolism, JBC，Pharmacological Research等杂志发表多篇SCI收录论文。研究成果获得湖北省科技进步一等奖（5/15），美国心脏病学会Paul Dudley White International Scholar Award（2021）。
E-mail:fuqin@mails.tjmu.edu.cn
目前主持的主要科研项目:
1.国家自然科学基金面上项目，PDE4调控的心脏成纤维细胞miR-1应答高胰岛素血症在糖尿病心肌纤维化中的作用机制及干预研究
2.国家自然科学基金海外及港澳学者合作研究基金延续项目，β2肾上腺素受体依赖性的胰岛素促心肌GLUT4转运对β受体阻滞剂抗糖尿病心力衰竭疗效的影响
3.国家自然科学基金面上项目，β2肾上腺素受体依赖性的胰岛素诱导的PDE4在糖尿病心功能不全中的作用
代表性学术论文(#第一作者,*通讯作者)：
1.Xu R#, Fu J#, Hu Y, Yang X, Tao X, Chen L, Huang K,Fu Q*. Roflumilast-Mediated Phosphodiesterase 4D Inhibition Reverses Diabetes-Associated Cardiac Dysfunction and Remodeling: Effects Beyond Glucose Lowering.Diabetes. 2022 May 20:db210898. doi: 10.2337/db21-0898
2.Ren H, Chen Y, Ao Z, Cheng Q, Yang X, Tao H, Zhao L, Shen A, Li P*,Fu Q*.PDE4D binds and interacts with YAP to cooperatively promote HCC progression.Cancer Lett. 2022 Aug 10;541:215749
3.Xu R, Feng S, Chen Y, Ao Z, Su C, Feng X,Fu Q*, Yang X*.Long-Acting β2 Adrenergic Receptor Agonist Ameliorates Imiquimod-Induced Psoriasis-Like Skin Lesion by Regulating Keratinocyte Proliferation and Apoptosis.Front. Pharmacol. 2022 June 20, https://doi.org/10.3389/fphar.2022.865715
4.Tao X, Chen C, Chen Y, Zhang L, Hu J, Yu H, Liang M,Fu Q*, Huang K*. β2-adrenergic receptor promotes liver regeneration partially through crosstalk with c-met.Cell Death Dis. 13, 571 (2022). https://doi.org/10.1038/s41419-022-04998-0
5.Tao X, He H, Peng J, Xu R, Fu J, Hu Y, Li L, Yang X, Feng X, Zhang C, Zhang L, Yu X, Shen A*, Huang K*,Fu Q*. Overexpression of PDE4D in mouse liver is sufficient to trigger NAFLD and hypertension in a CD36-TGF-β1 pathway: therapeutic role of roflumilast.Pharmacol Res. 2022 Jan;175:106004.
6.Xu R#, Gopireddy RR#, Wu Y#, Wu L, Tao X, Shao J, Wang W, Li L, Jovanovic A, Xu B, Kenyon NJ, Lu Q, Xiang YK*,Fu Q*. Hyperinsulinemia promotes heterologous desensitization of β2 adrenergic receptor in airway smooth muscle in obesity.FASEB J. 2020 Mar;34(3):3996-4008.
7.Tao X, Hu Y, Li L, Xu R, Fu J, Tong Q*,Fu Q*. Genetic deletion of β(2) adrenergic receptors exacerbates hepatocellular lipid accumulation in high-fat diet mice.BiochemBiophys Res Commun. 2019 Mar 26;511(1):73-78.
8.Fu Q*, Wang Q*, Xiang YK*Insulin and β Adrenergic Receptor Signaling: Crosstalk in Heart.Trends EndocrinolMetab. 2017 Jun;28(6):416-427 .
9.Wang Q#, Liu Y#,Fu Q#, Xu B, Zhang Y, Kim S, Tan R, Barbagallo F, West T, Anderson E, Wei W, Abel ED, Xiang YK. Inhibiting Insulin-Mediated β2-Adrenergic Receptor Activation Prevents Diabetes-Associated Cardiac Dysfunction.Circulation. 2017 Jan 3;135(1):73-88.
10.Fu Q#*,Kim S#, Soto D, De Arcangelis V, Dipilato L, Liu S, Xu B, Zhang J, Shi Q, Xiang YK*. A long-lasting β1 adrenergic receptor stimulation of cAMP/PKA signals in cardiac myocytes. J Biol Chem.2014 May 23;289(21):14771-81
11.Fu Q, Xu B, Liu Y, Parikh D, Li J, Li Y, Zhang Y, Riehle C, Zhu Y, Rawlings T, Shi Q, Clark RB, Chen X, Abel ED, Xiang YK. Insulin inhibits cardiac contractility by inducing a Gi-biased β2 adrenergic signaling in hearts.Diabetes.2014 Aug;63(8):2676-89
12.Fu Q*, Hu Y, Wang Q, Liu Y, Li N, Xu B, Kim S, Chiamvimonvat N, Xiang YK*. High-fat diet induces protein kinase A and G-protein receptor kinase phosphorylation of β(2) -adrenergic receptor and impairs cardiac adrenergic reserve in animal hearts.J Physiol. 2017 Mar 15;595(6):1973-1986.
13.Fu Q, Shi Q, West TM, Xiang YK. Cross-talk between insulin signaling and GPCRs.J CardiovascPharmacol. 2017 Aug;70 (2):74-86.
14.Fu Q, Xiang YK. Trafficking of β-Adrenergic Receptors: implications in intracellular receptor signaling.ProgMolBiolTransl Sci.2015;132:151-88
15.Fu Q*, Xu B, Parikh D, Cervantes D, Xiang YK. Insulin induces IRS2-dependent and GRK2-mediated β2AR internalization to attenuate βAR signaling in cardiomyocytes.Cell Signal.2015 Mar;27(3):707-15
16.Fu Q, Chen X, Xiang YK. Compartmentalization of β-adrenergic signals in cardiomyocytes.Trends Cardiovasc Med.2013 Oct;23(7):250-6
17.Zhang Q, Xiang J, Wang X, Liu H, Hu B, Feng M,Fu Q*. Beta(2)-adrenoceptor agonist clenbuterol reduces infarct size and myocardial apoptosis after myocardial ischaemia/reperfusion in anaesthetized rats.Br J Pharmacol. 2010 160(6):1561-72.
18.Liu P, Xiang JZ, Zhao L, Yang L, Hu BR,Fu Q*. Effect of beta2-adrenergic agonist clenbuterol on ischemia/reperfusion injury in isolated rat hearts and cardiomyocyte apoptosis induced by hydrogen peroxide. ActaPharmacol Sin. 2008 29(6):661-9
（Updated in June, 2022）
