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刘慧

发布者: [发表时间]:2018-10-12 [来源]: [浏览次数]:

1326

刘慧,女,博士,副教授,学系副主任,湖北省药理学会常务理事,“中国药理学会-施维雅青年药理学工作者奖”获得者,2003~2005年香港大学心血管研究所访问学者,2012~2014年香港大学李嘉诚医学院生理学系博士后人员。长期从事药理学的教学与科研工作,主持及参与多项国家自然科学基金、国家科技部科技攻关项目及省市级科研项目。

E-mailliuh@hust.edu.cn

研究方向:心血管和代谢性疾病及肿瘤靶点研究与药物研发

代表性论文(第一作者和*通讯作者文章):

1.Wu JZ, Du jx, LiZ, He W, Wang M, Jin MW, Yang L,Liu H*.Pentamethylquercetin Regulates Lipid Metabolism by Modulating Skeletal Muscle-Adipose Tissue Crosstalk in Obese Mice.Pharmaceutics.2022;14(6):1159

2.Li Z, Gao WQ, Wang P, Wang TQ, Xu WC, Zhu XY,Liu H*. Pentamethylquercetin Inhibits Hepatocellular Carcinoma Progression and Adipocytes-induced PD-L1 Expression via IFN-γ Signaling.Curr Cancer Drug Targets. 2020;20(11):868-874.

3.Li Z, Zhang C, Du JX, Zhao J, Shi MT, Jin MW,Liu H*. Adipocytes promote tumor progression and induce PD-L1 expression via TNF-α/IL-6 signaling.Cancer Cell Int. 2020;20: 179.

4.Du JX,Wu JZ,Li Z,Zhang C,Shi MT,Zhao J,Jin MW,Liu H*. Pentamethylquercetin protects against cardiac remodeling via activation of Sestrin2.Biochem Biophys Res Commun. 2019;512(2):412-420.

5.Han Y, Wu JZ, Shen JZ, Chen L, He T, Jin MW,Liu H*. Pentamethylquercetin induces adipose browning and exerts beneficial effects in 3T3-L1 adipocytes and high-fat diet-fed mice.Sci Rep. 2017;7(1):1123.

6.Liu H, Yang L, Wu HJ, Chen KH, Lin F, Li G, Sun HY, Xiao GS, Wang Y, Li GR. Water-soluble acacetin prodrug confers significant cardioprotection against ischemia/reperfusion injury.Sci Rep.2016;6:36435.

7.Liu H, Wang YJ, Yang L, Zhou M, Jin MW, Xiao GS, Wang Y, Sun HY, Li GR. Synthesis of a highly water-soluble acacetin prodrug for treating experimental atrial fibrillation in beagle dogs.Sci Rep. 2016;6:25743.

8.Liu H, Yang L, Chen KH, Sun HY, Jin MW, Xiao GS, Wang Y, Li GR. SKF-96365 blocks human ether-à-go-go-related gene potassium channels stably expressed in HEK 293 cells.Pharmacol Res. 2016;104:61-9.

9.Yang L,Liu H*, Sun HY, Li GR. Intravenous Anesthetic Propofol Inhibits Multiple Human Cardiac Potassium Channels.Anesthesiology.2015;122(3):571-84.

10.Feng M, Xiang JZ, Ming ZY, Fu Q, Ma R, Zhang QF, Dun YY, Yang L,Liu H*. Activation of epidermal growth factor receptor mediates reperfusion arrhythmias in anaesthetized rats.Cardiovasc Res. 2012;93(1):60-68.

11.Liu H, Yang L, Jin MW, Sun HY, Huang Y, Li GR. The selective estrogen receptor modulator raloxifene inhibits cardiac delayed rectifier potassium currents and voltage-gated sodium current without QTc interval prolongation.Pharmacol Res. 2010;62(5):384-90.

12.Liu H, Sun HY, Lau CP, Li GR. Regulation of voltage-gated cardiac sodium current by epidermal growth factor receptor kinase in guinea pig ventricular myocytes.J Mol Cell Cardiol. 2007;42(4):760-768.

13.Liu H, Jin MW, Xiang JZ, Huang Y, Sun HY, Chiu SW, Lau CP, Li GR.Raloxifene inhibits transient outward and ultra-rapid delayed rectifier potassium currents in human atrial myocytes.Eur J Pharmacol. 2007;563(1-3):61-8.

14.Liu H, Hu B, Fu H, Xiang J, Liu L. Effects of Phorbol-12,13-dibuterate on Sodium Currents and Potassium Currents in Rat Trigeminal Ganglion Neurons.Journal of Huanzhong University of Science and Technology(Med Sci), 2007;27(1):1-4.

(Updated in June, 2022)