陈伟，教授，博士生导师，国家海外高层次青年人才（2022），湖北省“杰青”（2022），湖北省“百人计划”（2021）入选者。陈教授2009年于武汉大学化学基地班专业获理学学士学位，2014年在浙江大学化学系获得博士学位。2015-2018年在美国国立卫生研究院National Institutes of Health（NIH）陈小元教授课题组从事博士后研究，2018-2020年于麻省理工学院（Massachusetts Institute of Technology, MIT）Robert S. Langer教授（美国三院院士，2021年增选为中国工程院外籍院士）课题组任研究科学家（Research Scientist）。2021年加入华中科技大学同济医学院基础医学院药理学系，任教授，兼任Chinese Chemical Letters和MedComm-Biomaterials and Application青年编委，以及Journal of Nanobiotechnology客座编辑。同时担任湖北省药理学会理事以及中国抗癌协会第三届纳米肿瘤学专业委员会委员。
研究方向：智能器件，仿生修饰，转化医学，诊断治疗，药物可控释放，长效药物制剂
联系方式：weichen86@hust.edu.cn/weichensci@hotmail.com, 欢迎材料，化学，生物，医学，工程等相关专业学生报考。
个人主页：https://weichenacademic.wordpress.com
华中科技大学同济医学院基础医学院陈伟转化医学课题组
陈教授长期从事利用生物启发技术构建药物制剂及智能器件用于疾病诊断治疗的研究。围绕着克服肿瘤耐药性、提升病人依从性以及增加生物样本采样准确性等关键临床问题，陈教授基于前期研究背景，学习并借鉴自然界中存在生物原理，发展了系列生物启发智能系统：（1）制备仿生矿化药物制剂，逆转了肿瘤耐药性；（2）开发了生物表面修饰及改性技术，调控生物体定向迁移特性；（3）成功构建了血糖响应型微针贴片，便利、长效调控病人血糖；（4）创造超强生物粘附微针药片，实现了大分子药物高效口服递送；（5）发展可富集病毒微针咽拭子提高了新冠病毒检测准确性。目前已发表SCI论文30余篇，包括ACS Nano (2023), Adv. Sci. (2023), J. Control. Release (2023), Device (2023), Sci. Adv. (2022), Adv. Mater. (2022), Nano Lett. (2022), ACS Nano (2022)，Theranostics (2021)，Matter (2020), Nano Today (2020), Nano Lett. (2019), Adv. Drug Deliv. Rev. (2018), Nat. Commun. (2017), ACS nano (2017), Small (三篇，2014一篇，2015两篇), J. Control. Release (2015)等。申请了多项中国或美国专利，4项已获授权。以重要骨干身份参与了美国国立卫生研究院内部研究计划，以及麻省理工学院-诺和诺德联合研究项目。陈教授的工作具有较大的国际影响力，成果被美国国立卫生研究院（NIH）和麻省理工学院（MIT）推荐，并被Cell出版社以及多家媒体相继转载。陈教授的工作已展现出较高的商业及临床转化潜力，被糖尿病药物公司诺和诺德邀请参与药物制剂的研发，相关工作已进入临床试验阶段。
部分代表性工作概览
代表性论文：
1. Gong, Yusheng; Tong, Shuai; Li, Xixuan; Chen, Xiuli; Liu, Yuan; Li, Nan; Xu, Jiarong; Xu, Rengui; Guo, Yusong; Xiao, Fei; Chen, Xiaoyuan*; Chen, Wei*, Intestinal villi-inspired mathematically base-layer engineered microneedles (IMBEMs) for effective molecular exchange during biomarker enrichment and drug deposition in diversified mucosa,ACS Nano2023, 10.1021/acsnano.3c02944.
2. Xu, Jiarong; Zeng, Qi; Chen, Xiuli; Guo, Honglian; Gong, Yusheng; Xu, Rengui; Cao, Peng; Wei, Chunyu; Xiao, Fei; Jiang, Dawei*; Chen, Wei*, Iron (III) cross-linked alginate microneedle patch for xerosis treatment based on controllable photodegradation,Chem. Eng. J.2023, 145672.
3. Chen, Xiuli; Gong, Yusheng; Chen, Wei.*, Advanced temporally-spatially precise technologies for on-demand neurological disorder intervention,Adv. Sci.2023,10(14), e2207436.
4. Wang, Zheng#; Li, Qilin#; Cao, Peng#; Zhang, Jiao; Wu, Di; Xu, Rengui; Zhang, Yan; Xu, Yunruo; Liang, Tao; Chen, Wei*; Wang, Lin*; Chen, Xiaouan*, A biomimetic helical robot actuated by rotating magnetic field for targeted navigation and NIR-based prodrug activation to treat intestinal diseases,Device2023, Accepted, Under publication.
5. Xu, Rengui; Guo, Honglian; Chen, Xiuli; Xu, Jiarong; Gong, Yusheng; Cao, Peng; Wei, Chunyu; Xiao, Fei; Wu, Di; Chen, Wei*; Wang, Lin*; Wang, Zheng*, Smart hydrothermally responsive microneedle for topical tumor treatment,J. Control. Release2023,358, 566-578.
6. Dai, Jun#; Wei, Siming#; Xu, Jiarong#; Xue, Huiying; Chen, Zhaojun; Wu, Meng; Chen, Wei*; Lou, Xiaoding; Xia, Fan*; Wang, Shixuan*, Microneedle device delivering aggregation-induced emission photosensitizers for enhanced metronomic photodynamic therapy of cancer,ACS Appl. Mater. Interfaces2023,15, 16526–16538.
7. Yu, Yajie#; Lv, Bing#; Wu, Juntao; Chen, Wei*, Mussel-based biomimetic strategies in musculoskeletal disorder treatment: from synthesis principles to diverse applications,Int. J. Nanomedicine2023,18, 455-472.
8. Liu, Yuan; Huang, Ting; Qian, Zhiyong*; Chen, Wei*, Extensible and swellable hydrogel-forming microneedles for deep point-of-care sampling and drug deployment,Chin. Chem. Lett.2023, 108103.
9. Chen, Wei; Wainer, Jacob; Ryoo, Si Won; Qi, Xiaoyue; Chang, Rrong; Li, Jason; Lee, Seung Ho; Min, Seokkee; Wentworth, Adam; Collins, Joy; Tamang, Siddartha; Ishida, Keiko; Hayward, Alison; Langer, Robert; Traverso, Giovanni*, Dynamic omnidirectional adhesive microneedle system for oral macromolecular drug delivery,Sci. Adv.2022,8, eabk1792.
10. Chen, Wei*; Wang, Zheng*; Wang, Lin*; Chen, Xiaoyuan*, Smart chemical engineering‐based lightweight and miniaturized attachable systems for advanced drug delivery and diagnostics,Adv. Mater.2022,34(6), 2106701.
11. Huang, Haoming#; Hu, Dian#; Chen, Zhuo#; Xu, Jiarong; Xu, Rengui; Gong, Yusheng; Fang, Zhengming; Wang, Ting*; Chen, Wei*, Immunotherapy for type 1 diabetes mellitus by adjuvant-free Schistosoma japonicum-egg tip-loaded asymmetric microneedle patch (STAMP),J. Nanobiotechnology2022,20(1), 377.
12. Li, Qilin#; Xu, Rengui#; Fan, Huiling#; Xu, Jiarong; Xu, Yunruo; Cao, Peng; Zhang, Yan; Liang, Tao; Zhang, Yang; Chen, Wei*; Wang, Zheng*; Wang, Lin*; Chen, Xiaoyuan*, Smart mushroom-inspired imprintable and lightly detachable (MILD) microneedle patterns for effective COVID-19 vaccination and decentralized information storage,ACS Nano2022,16(5), 7512-7524.
13. Deng, Yan#; Yang, Cheng#; Zhu, Yuanyuan; Liu, Wenyu; Li, Heli; Wang, Liping; Chen, Wei*; Wang, Zheng*; Wang, Lin*, Lamprey-teeth-inspired oriented antibacterial sericin microneedles for infected wound healing improvement,Nano Lett.2022,22(7), 2702-2711.
14. Liu, Yuan; Guo, Honglian; Xu, Rengui; Chen, Wei*, Smart intraoral systems for advanced drug delivery,MedComm – Biomaterials and Applications.2022,1, e19.
15. Cai, Bo#; Gong, Yusheng#; Wang, Zheng*; Wang, Lin*; Chen, Wei*, Microneedle arrays integrated with living organisms for smart biomedical applications,Theranostics2021,11(20), 10012-10029.
16. Chen, Wei#; Huang, Ting#; Shi, Kun; Chu, Bingyang; Qian, Zhiyong*, Chemotaxis-based self-accumulation of surface-engineered mitochondria for cancer therapeutic improvement,Nano Today2020,35, 100966.
17. Chen, Wei*; Cai, Bo; Geng, Zhi; Chen, Fenghua; Wang, Zheng*; Wang, Lin*; Chen, Xiaoyuan*, Reducing false negatives in COVID-19 testing by using microneedle-based oropharyngeal swabs,Matter2020,3(5), 1589-1600.
18. Chen, Wei; Shi, Kun; Chu, Bingyang; Wei, Xiawei*; Qian, Zhiyong*, Mitochondrial surface engineering for multidrug resistance reversal,Nano Lett.2019,19(5), 2905-2913.
19. Chen, Wei; Yung, Bryant C; Qian, Zhiyong*; Chen, Xiaoyuan*, Improving long-term subcutaneous drug delivery by regulating material-bioenvironment interaction,Adv. Drug Deliv. Rev.2018,127, 20-34.
20. Chen, Wei; Tian, Rui; Xu, Can; Yung, Bryant C.; Wang, Guohao; Liu, Yijing; Ni, Qianqian; Zhang, Fuwu; Zhou, Zijian; Wang, Jingjing; Niu, Gang; Ma, Ying; Fu, Liwu*; Chen, Xiaoyuan*, Microneedle-array patches loaded with dual mineralized protein/peptide particles for type 2 diabetes therapy,Nat. Commun.2017, 1777.
21. Chen, Wei; Wang, Guohao; Yung, Bryant C.; Liu, Gang; Qian, Zhiyong*; Chen, Xiaoyuan*, Long-acting release formulation of exendin-4 based on biomimetic mineralization for type 2 diabetes therapy,ACS Nano2017,11(5), 5062-5069.
22. Chen, Wei; Wang, Fang; Zhang, Xu; Hu, Jing; Wang, Xiaokun; Yang, Ke; Huang, Liyan; Xu, Meng; Li, Qingshan; Fu, Liwu*, Overcoming ABCG2-mediated multidrug resistance by a mineralized hyaluronan–drug nanocomplex,J. Mater. Chem. B2016,4(41), 6652-6661.
23. Rao, Yuefeng#; Chen, Wei#; Liang, Xingguang; Huang, Yongzhuo; Miao, Jing; Liu, Liu; Lou, Yan; Zhang, Xingguo; Wang, Ben; Tang, Ruikang; Chen, Zhong; Lu, Xiaoyang*, Epirubicin‐loaded superparamagnetic iron‐oxide nanoparticles for transdermal delivery: cancer therapy by circumventing the skin barrier,Small2015,11(2), 239-247.
24. Chen, Wei; Liu, Xueyao; Xiao, Yun; Tang, Ruikang*, Overcoming multiple drug resistance by spatial–temporal synchronization of epirubicin and pooled siRNAs,Small2015,11(15), 1775-1781.
25. Chen, Wei; Fu, Liwu*; Chen, Xiaoyuan*, Improving cell-based therapies by nanomodification,J. Control. Release2015,219, 560-575.
26. Chen, Wei; Wang, Guangchuan; Tang, Ruikang*, Nanomodification of living organisms by biomimetic mineralization,Nano Res.2014,7(10), 1404-1428.
27. Chen, Wei; Liu, Xueyao; Xiao, Yun; Chen, Yanhong; Wang, Guangchuan; Liu, Cuilian; Xu, Xurong; Tang, Ruikang*, Nano regulation of cisplatin chemotherapeutic behaviors by biomineralization controls,Small2014,10(18), 3644-3649.
28. Chen, Wei; Xiao, Yun; Liu, Xueyao; Chen, Yanhong; Zhang, Jiaojiao; Xu, Xurong; Tang, Ruikang*, Overcoming cisplatin resistance in chemotherapy by biomineralization,Chem. Commun.2013,49(43), 4932-4934.
29. Lv, Qiying#; Li, Xiaoye#; Tian, Xin; Fu, Da‐an; Liu, Huan; Liu, Jia; Song, Yu; Cai, Bo; Wang, Jian; Su, Qiangfei; Chen, Wei; Zou, Meizhen; Xiao, Fei; Wang, Shuai*; Wang, Zheng*; Wang, Lin*, A degradable and biocompatible supercapacitor implant based on functional sericin hydrogel electrode,Adv. Energy Mater.2023, 2203814.
30. Lee, Seung Ho; Wan, Qianqian; Wentworth, Adam; Ballinger, Ian; Ishida, Keiko; Collins, Joy E; Tamang, Siddartha; Huang, Hen-Wei; Li, Canchen; Hess, Kaitlyn; Lopes, Aaron; Kirtane, Ameya; Lee, Jung Seung; Lee, Sejun; Chen, Wei; Wong, Kaithlyn; Selsing, George; Kim, Hyunjoon; Buckley, Stephen; Hayward, Alison; Langer, Robert; Traverso, Giovanni*, Implantable system for chronotherapy,Sci. Adv.2021,7(48), eabj4624.
31. Zhou, Zijian; Chan, Alexander; Wang, Zhantong; Huang, Xiaolin; Yu, Guocan; Jacobson, Orit; Wang, Sheng; Liu, Yijing; Shan, Lingling; Dai, Yunlu; Shen, Zheyu; Lin, Lisen; Chen, Wei; Chen, Xiaoyuan*, Synchronous chemoradiation nanovesicles by x-ray triggered cascade of drug release,Angew. Chem. Int. Ed. Engl.2018,57(28), 8463-8467.
32. Xia, Yuqiong*; Wang, Xiaofei; Cheng, He; Fang, Mei; Ning, Pengbo; Zhou, Yulu; Chen, Wei; Song, Hongjin, A polycation coated liposome as efficient siRNA carrier to overcome multidrug resistance,Colloids Surf. B Biointerfaces2017,159, 427-436.
33. Wang, Zhe; Zhang, Fuwu; Wang, Zhantong; Liu, Yijing; Fu, Xiao; Jin, Albert; Yung, Bryant C; Chen, Wei; Fan, Jing; Yang, Xiangyu; Niu, Gang; Chen, Xiaoyuan*, Hierarchical assembly of bioactive amphiphilic molecule pairs into supramolecular nanofibril self-supportive scaffolds for stem cell differentiation,J. Am. Chem. Soc.2016,138(45), 15027-15034.
34. Liu, Zhaoming; Xiao, Yun; Chen, Wei; Wang, Yang; Wang, Ben; Wang, Gguangchuan; Xu, Xurong; Tang, Ruikang*, Calcium phosphate nanoparticles primarily induce cell necrosis through lysosomal rupture: the origination of material cytotoxicity,J. Mater. Chem B.2014,2(22), 3480-3489.
35. Wang, Yang; Xiao, Yun; Zhou, Hangyu; Chen, Wei; Tang, Ruikang*, Ultra-high payload of doxorubicin and pH-responsive drug release in CuS nanocages for a combination of chemotherapy and photothermal therapy,RSC Adv.2013,3(45), 23133-23138.
36. Du, Yuhao#; Zhang, Dan#; Chen, Wei; Zhang, Ming; Zhou, Yangyang; Zhou, Xiang*, Cationic N-confused porphyrin derivative as a better molecule scaffold for G-quadruplex recognition,Bioorgan. Med. Chem.2010,18(3), 1111-1116.
37. Wang, Guangchuan; Li, Xiaofeng; Mo, Lijuan; Song, Zhiyong; Chen, Wei; Deng, Yongqiang; Zhao, Hui; Qin, Ede; Qin, Chengfeng*; Tang, Ruikang*, Eggshell-Inspired Biomineralization Generates Vaccines that Do Not Require Refrigeration,Angew. Chem. Int. Ed. Engl.2012,51(42), 10576-10579.
专利：
1. 陈卓; 陈伟; 王婷, 不对称缺口设计的微针贴片, 外观设计专利 202330314259.3, 2023.05.25。
2. 陈卓; 陈伟; 王婷, 口腔黏膜微针, 外观设计专利 202321497964.2, 2023.06.13。
3. 陈卓; 王婷; 陈伟, 一种搭载旋毛虫虫源性蛋白的双相口腔黏膜微针贴片, 实用新型专利 202321497964.2, 2023.06.13。
4. 陈卓; 陈伟; 王婷, 一种尖端装载血吸虫虫卵冻干粉的不对称微针贴片, 实用新型专利 202321288674.7, 2023.05.25。
5. 王琳; 王征; 陈伟; 许仁珪, 水热响应微针贴片及其制备方法和应用, 中国发明专利 202211096332.5, 2023.01.24。
6. 陈伟; 龚宇晟, 一种数学模拟优化底纹的智能微针贴片及其制备方法, 中国发明专利 202210569904.0, 2022.09.09。
7. 王琳; 王征; 陈伟; 范慧玲; 许仁珪; 李琪琳, 一种可递药及在体原位标记的可分离微针阵列及其制备方法, 中国发明专利 202210003636.6, 2022.05.27。
8. 王征; 王琳; 陈伟; 李琪琳; 曹鹏, 一种肠道药物递送的仿生机器人系统及其制备方法和应用, 中国发明专利 202210580750.5, 2022.08.05。
9. 陈小元; 陈伟, 矿化艾塞那肽缓释体系及其制备方法和应用, 中国发明专利 201710279366.0, 2021.04.20。
10. 陈伟; 王琳; 王征; 陈小元; 蔡博; 陈凤花, 一种可自发富集病毒的微针拭子的制备方法及其应用, 中国发明专利 202011068192.1, 2021.08.06。
11. 王琳; 王征; 陈伟; 邓炎; 杨诚, 一种七鳃鳗牙齿形状仿生的抗菌丝胶微针的制备及其生物应用, 中国发明专利 202111009034.3, 2021.11.19。
12. 陈小元; 陈伟, 一种葡萄糖响应性艾塞那肽微针贴片及其制备方法, 中国发明专利 201710362155.3, 2020.06.19。
13. 陈伟; 肖云; 刘雪瑶; 陈燕红; 章娇娇; 徐旭荣; 唐睿康, 一种抗耐药性的顺铂矿化液及其制备方法和应用, 中国发明专利 201210571654.0, 2015.04.22。
(Updated in August,2023)
