当前位置: 网站首页 >> 师资队伍 >> 正文

陈伟

发布者: [发表时间]:2020-11-29 [来源]: [浏览次数]:

陈伟,博士,华中科技大学药理学系教授,华中卓越学者,博士生导师,2009年于武汉大学化学基地班专业获理学学士学位,2014年在浙江大学化学系获得博士学位。2015-2018年在美国国立卫生研究院National Institutes of Health (NIH)陈小元教授课题组从事博士后研究,2018-2020年于麻省理工学院(Massachusetts Institute of Technology, MIT)Robert S. Langer教授课题组任研究科学家(Research Scientist).

研究方向:智能器件,仿生修饰,转化医学,诊断治疗,药物可控释放,长效药物制剂

联系方式weichen86@hust.edu.cn,欢迎材料,化学,生物,医学,工程等相关专业学生报考。

目前已构建多种药物材料复合体系,皮下以及口服智能生物器件等,实现了肿瘤耐药性逆转以及长效的糖尿病治疗。取得多项成果,以第一作者身份在Nature Communications, Nano today, Nano Letters, Advanced Drug Delivery Reviews, ACS nano, Journal of Controlled Release, Small, Chemical Communications, Matter等高水平国际期刊中发表论文多篇,申请3项中国以及美国发明专利,为Advanced Drug Delivery Reviews, Biomaterials, Theranostics, Journal of Biomedical Nanotechnology等期刊特约审稿人。

代表性论文:

1. Chen, W.; Tian, R.; Xu, C.; Yung, B. C.; Wang, G.; Liu, Y.; Ni, Q.; Zhang, F.; Zhou, Z.; Wang, J.; Niu, G.; Ma, Y.; Fu, L.*; Chen, X.*, Microneedle-array patches loaded with dual mineralized protein/peptide particles for type 2 diabetes therapy.Nat. Commun.2017,8(1), 1777.

2. Chen, W.; Wang, G.; Yung, B. C.; Liu, G.; Qian, Z.*; Chen, X.*, Long-acting release formulation of exendin-4 based on biomimetic mineralization for type 2 diabetes therapy.ACS Nano2017,11(5), 5062-5069.

3. Chen, W.; Yung, B. C.; Qian, Z.*; Chen, X.*, Improving long-term subcutaneous drug delivery by regulating material-bioenvironment interaction.Advanced drug delivery reviews2018,127, 20-34.

4. Chen, W.*; Cai, B.; Geng, Z.; Chen, F.; Wang, Z.*; Wang, L.*; Chen, X.*, Reducing false negatives in COVID-19 testing by using microneedle-based oropharyngeal swabs.Matter2020,3, 1589-1600.

5. Chen, W. (co-first); Huang, T.; Shi, K.; Chu, B.; Qian, Z.*, Chemotaxis-based self-accumulation of surface-engineered mitochondria for cancer therapeutic improvement.Nano Today2020,35, 100966.

6. Chen, W.; Shi, K.; Chu, B.; Wei, X.; Qian, Z.*,Mitochondrial surface engineering for multidrug resistance reversal.Nano Lett.2019,19(5), 2905-2913.

7. Chen, W.; Liu, X.; Xiao, Y.; Tang, R.*, Overcoming multiple drug resistance by spatial-temporal synchronization of epirubicin and pooled siRNAs.Small2015,11(15), 1775-1781.

8 Chen, W.; Fu, L.*; Chen, X.*, Improving cell-based therapies by nanomodification.J. Control. Release2015,219, 560-575.

9. Rao, Y.;Chen, W. (co-first); Liang, X.; Huang, Y.; Miao, J.; Liu, L.; Lou, Y.; Zhang, X.; Wang, B.; Tang, R.; Chen, Z.; Lu, X.*, Epirubicin-loaded superparamagnetic iron-oxide nanoparticles for transdermal delivery: cancer therapy by circumventing the skin barrier.Small2015,11(2), 239-247.

10. Chen, W.; Liu, X.; Xiao, Y.; Chen, Y.; Wang, G.; Liu, C.; Xu, X.; Tang, R.*, Nano regulation of cisplatin chemotherapeutic behaviors by biomineralization controls.Small2014,10(18), 3644-3649.

11. Chen, W.; Wang, G.; Tang, R.*, Nanomodification of living organisms by biomimetic mineralization.Nano Research2014,7(10), 1404-1428.

12. Chen, W.; Wang, F.; Zhang, X.; Hu, J.; Wang, X.; Yang, K.; Huang, L.; Xu, M.; Li, Q.; Fu, L.*, Overcoming ABCG2-mediated multidrug resistance by a mineralized hyaluronan-drug nanocomplex.J. Mater. Chem. B2016,4(41), 6652-6661.

13. Chen, W.; Xiao, Y.; Liu, X.; Chen, Y.; Zhang, J.; Xu, X.; Tang, R.*, Overcoming cisplatin resistance in chemotherapy by biomineralization.Chem. Commun.2013,49(43), 4932-4934.

14. Zhou, Z.*; Chan, A.; Wang, Z.; Huang, X.; Yu, G.; Jacobson, O.; Wang, S.; Liu, Y.; Shan, L.; Dai, Y.; Shen, Z.; Lin, L.;Chen, W.; Chen, X.*, Synchronous chemoradiation nanovesicles by x-ray triggered cascade of drug release.Angew. Chem. Int. Ed. Engl.2018,57(28), 8463-8467.

15. Wang, Z.; Zhang, F.; Wang, Z.; Liu, Y.; Fu, X.; Jin, A.; Yung, B. C.;Chen, W.; Fan, J.; Yang, X.; Niu, G.; Chen, X.*, Hierarchical assembly of bioactive amphiphilic molecule pairs into supramolecular nanofibril self-supportive scaffolds for stem cell differentiation.J. Am. Chem. Soc.2016,138(45), 15027-15034.

16. Xia, Y.*; Wang, X.; Cheng, H.; Fang, M.; Ning, P.; Zhou, Y.;Chen, W.; Song, H.,A polycation coated liposome as efficient siRNA carrier to overcome multidrug resistance.Colloids Surf. B Biointerfaces2017,159, 427-436.

17 Liu Z.; Xiao Y.; Chen W.; Wang Y.; Wang B.; Wang G.; Xu X.; Tang R.* Calcium phosphate nanoparticles primarily induce cell necrosis through lysosomal rupture: the origination of material cytotoxicity. J Mater Chem B, 2014, 2, 3480-3489.

18. Wang, G.; Li, X.; Mo, L.; Song, Z.;Chen, W.; Deng, Y.; Zhao, H.; Qin, E.; Qin, C.*; Tang, R.*, Eggshell-inspired biomineralization generates vaccines that do not require refrigeration.Angew. Chem. Int. Ed. Engl.2012,51(42), 10576-10579.

19. Wang, Y.; Xiao, Y.; Zhou, H.;Chen, W.; Tang, R.*, Ultra-high payload of doxorubicin and pH-responsive drug release in CuS nanocages for a combination of chemotherapy and photothermal therapy.RSC Advances2013,3(45), 23133-23138.

20. Du, Y.; Zhang, D.;Chen, W.; Zhang, M.; Zhou, Y.; Zhou, X.*, Cationic N-confused porphyrin derivative as a better molecule scaffold for G-quadruplex recognition.Bioorg. Med. Chem.2010,18(3), 1111-1116.