一、人员组成

教授：郭莲军

副教授:徐旭林吕青

二、研究方向

脑中风是公认的、对人民健康造成威胁最广泛的疾病之一，中风又分为出血性和缺血性中风，其中缺血性中风的发生率高于出血性中风，慢性脑缺血是导致血管性痴呆主要原因，并且约有三分之一的脑缺血病人会出现情感障碍，严重影响了患者的康复，给家庭和社会带来沉重的负担。慢性脑缺血的病理损伤机制复杂，目前，针对该疾病的研究多集中在急性缺血期，或急性缺血后较短时间内，因此，深入研究慢性脑缺血发生的病理生理机制,寻找慢性脑缺血治疗的新靶点并开发相应的药物有重要意义。课题组主要研究方向：（1）慢性脑缺血损伤的分子机制研究；（2）缺血预适应的保护机制；（3）有关抗脑缺血新药的开发研究。

三、承担的主要科研项目：

1、国家自然科学基金：Ih通道对脑缺血海马NMDA受体亚型功能性重组的调节

2、国家自然科学基金：脑缺血时海马HCN1通道改变对谷氨酸释放的影响

3、国家自然科学基金：脑缺血时兴奋性与抑制性氨基酸受体间对话研究

4、国家自然科学基金：慢性脑低灌损伤HCN2对海马GABA抑制性中间神经元突触可塑性的修饰调节

5、国家自然科学基金：Toll样受体介导的TRIF信号通路在脑缺血预适应炎症抑制中的作用研究

6、湖北省自然科学基金：中药抗氧化剂-茶多酚对血管性痴呆防治作用及机制研究

7、湖北省自然科学基金：Kv7/M 通道在慢性应激所致学习记忆功能障碍中的作用及机制研究

8、华中科技大学自主创新基金：信号对慢性应激大鼠海马神经发生的调控作用及其机制研究

9、华中科技大学自主创新基金：Kv7通道在慢性应激抑郁模型小鼠海马神经髓鞘再生中的作用及调控机制研究

10、华中科技大学自主创新基金：STAT3/SOCS3负调控TLRs-TRAF6信号通路参与脑缺血预适应保护作用研究

11.教育部留学回国人员科研启动基金：胶质细胞谷氨酸转运体在脑缺血预适应中的作用及其PKC信号调控机制

四、代表性论文

1. Activation of GABAB receptors ameliorates cognitive impairment via restoring the balance of HCN1/HCN2 surface expression in the hippocampal CA1 area in rats with chronic cerebral hypoperfusion. Li CJ, Lu Y, Zhou M, Zong XG, Li C, Xu XL,Guo LJ, Lu Q. Mol Neurobiol.2014Oct;50(2):704-20.

2.Astrocytic Toll-like receptor 3 is associated with ischemic preconditioning-induced protection against brain ischemia in rodents. Pan LN, Zhu W, Li Y, Xu XL,Guo LJ, Lu Q, Wang J. PLoS One.2014Jun 10;9(6):e99526. doi: 10.1371/journal.

3. Imbalance of HCN1 and HCN2 expression in hippocampal CA1 area impairs spatial learning and memory in rats with chronic morphine exposure. Zhou M, Luo P, Lu Y, Li CJ, Wang DS, Lu Q, Xu XL, He Z,Guo LJ. Prog Neuropsychopharmacol Biol Psychiatry.2014Oct 7;56C:207-214.

4.Electrophysiological properties of hippocampal-cortical neural networks, role in the processes of learning and memory in rats. Li CJ, Lu Y, Zhou M,Guo LJ. J Neural Transm.2014Jun;121(6):583-92.

5.KCNQ/Kv7 channel activator flupirtine protects against acute stress-induced impairments of spatial memory retrieval and hippocampal LTP in rats.Li C, Huang P, Lu Q, Zhou M,Guo L, Xu X. Neuroscience.2014Sep 16;280C:19-30. doi: 10.1016/j.

6 Low Dose ZD7288 Attenuates the Ischemia/Reperfusion-Induced Impairment of Long-Term Potentiation Induction at Hippocampal Schaffer Collateral-CA1 Synapses. Wei He. Xulin Xu . Qing Lv . Lianjun Guo. Cellular and Molecular Neurobiology: 2014，34（4）：611-617

7.Pan Luo，Yun Lu，Changjun Li，Mei Zhou，Cheng Chen，Qing Lu，Xulin Xu，Zhi He，Lianjun Guo.Long-lasting spatial learning and memory impairments caused by chronic cerebral hypoperfusion associate with a dynamic change of HCN1/HCN2 expression in hippocampal CA1region. Neurobiology of Learning and Memory.2015,123:72-83.

8.Yun Lu, Changjun Li , Mei Zhou, Pan Luo, Pengcheng Huang, Jiahong Tan, Qing Lu, Xulin Xu,Zhi He , Lianjun Guo.Clonidine ameliorates cognitive impairment induced by chronic cerebral hypoperfusion via up-regulation of the GABABR1 and GAD67 in hippocampal CA1 in rats. Pharmacology, Biochemistry and Behavior 132 (2015) 96–102.

9.Mei Zhou, Pan Luo, Yun Lu , Chang-jun Li, Dian-shiWang , Qing Lu, Xu-lin Xu,Zhi He,Lian-jun GuoImbalance of HCN1 and HCN2 expression in hippocampal CA1 area impairs spatial learning and memory in rats with chronic morphine exposure. Progress in Neuro-Psychopharmacology & Biological Psychiatry 56 (2015) 207–214.

10.Pan Luo and Lianjun.HCN Channels: From the Role in Chronic Cerebral Hypoperfusion-Induced Cognitive Impairments to a New Therapeutic Target for Vascular Dementia.Neurology & Neurophysiology 2015.6（4）：1-6.

11.Li Y, Xu XL, Zhao D, Pan LN, Huang CW, Guo LJ, Lu Q, Wang J.TLR3 ligand Poly IC Attenuates Reactive Astrogliosis and Improves Recovery of Rats after Focal Cerebral Ischemia. CNS Neurosci Ther. 2015 Nov;21(11):905-13.

12. Li C, Lu Q, Huang P, Fu T, Li C, GuoL, Xu X.Activity-dependent downregulation of M-Type (Kv7) K⁺channels surface expression requires the activation of iGluRs/Ca²⁺/PKC signaling pathway in hippocampal neuron.Neuropharmacology.2015 Aug;95:154-67.

13.Huang P, Li C, Fu T, Zhao D, Yi Z, Lu Q, Guo L, Xu X. Flupirtine attenuates chronic restraint stress-induced cognitive deficits and hippocampal apoptosis in male mice.Behav Brain Res. 2015 Jul 15;288:1-10.

14.Lu Y, Li CJ, Chen C, Luo P, Zhou M, Li C, Xu XL, Lu Q, He Z, Guo LJ.

Activation of GABAB2 subunits alleviates chronic cerebral hypoperfusion-induced anxiety-like behaviours: A role for BDNF signalling and Kir3 channels. Neuropharmacology(0028-3908). 2016 Nov;110(Pt A):308-21.

15.Luo P, Chen C, Lu Y, Fu T, Lu Q, Xu X, Li C, He Z, Guo L*

Baclofen ameliorates spatial working memory impairments induced by chronic cerebral hypoperfusion via up-regulation of HCN2 expression in the PFC in rats.

Behav Brain Res(0166-4328). 2016 Jul 15;308:6-13.

16.Luo P, Zhang X, Lu Y, Chen C, Li C, Zhou M, Lu Q, Xu X, Shen G4, Guo L*.

Fluoxetine ameliorates cognitive impairments induced by chronic cerebral hypoperfusion

via down-regulation of HCN2 surface expression in the hippocampal CA1 area in rats

Pharmacology, Biochemistry and Behavior.2016 Jan;140:1-7

17.Zhu W, Cao FS, Feng J, Chen HW, Wan JR, Lu Q, Wang J. NLRP3 inflammasome activation contributes to long-term behavioral alterations in mice injected with lipopolysaccharide.Neuroscience.2017 Feb 20;343:77-84.

五、奖励与荣誉：

卫生部科技成果进步奖三等奖：下丘脑氨基酸类神经递质释放特点

六、专利

专利名称：米邦塔仙人掌多糖在防治慢性神经退行性疾病中的应用 专利申请号：2010101995305