一、人员组成

教授：明章银

副教授：马嵘

二、研究方向

1.血小板粘附激活的分子机制

2.血小板相关疾病（肿瘤、心脑血管等疾病）的发病机制和干预靶点

3.心脑血管药理学

4.新药开发与评价 

三、代表性科研项目：

1.ADAM10-CX3CL1轴在血小板促进肝癌转移中的作用及机制研究，项目负责人，国家自然科学基金面上项目，在研

2.血小板膜受体GPVI在急性肾损伤中的作用和机制研究，项目负责人，国家自然科学基金面上项目，在研

3.战场创伤出血的快速止血研究，项目负责人，装备预研教育部联合基金，已结题

4.FcγRIIa介导的血小板激活及KLF6在血小板促肝癌生长和转移中的作用及机制研究，项目负责人，国家自然科学基金面上项目，已结题

5.血小板FcγRIIa介导αIIbβ3 "由外向内"信号转导机制研究，项目负责人，国家自然科学基金面上项目，已结题

6.丹参新酮对血小板的作用及其机制研究，项目负责人，湖北省卫健委中医药重点项目，已结题

四、代表性论文：

1.Zhu Y, Shu D, Gong X, Lu M, Feng Q, Zeng XB, Zhang H, Gao J, Guo YW, Liu L, Ma R, Zhu L, Hu Q,Ming ZY*(明章银). Platelet-Derived TGF (Transforming Growth Factor)-β1 Enhances the Aerobic Glycolysis of Pulmonary Arterial Smooth Muscle Cells by PKM2 (Pyruvate Kinase Muscle Isoform 2) Upregulation. Hypertension. 2022 May;79(5):932-945.（IF = 9.897）

2.Shu D, Zhu Y, Lu M, He AD, Chen JB, Ye DS, Liu Y, Zeng XB, Ma R,Ming ZY*(明章银). Sanguinarine Attenuates Collagen-Induced Platelet Activation and Thrombus Formation. Biomedicines. 2021 Apr 21;9(5):444.（IF = 4.757）

3.Miao S, Lu M, Liu Y, Shu D, Zhu Y, Song W, Ma Y, Ma R, Zhang B, Fang C,Ming ZY*(明章银).Platelets are recruited to hepatocellular carcinoma tissues in a CX3CL1-CX3CR1 dependent manner and induce tumour cell apoptosis.Mol Oncol. 2020 Aug 15;14(10):2546-59. (IF= 7.449)

4.Yang RP, Zhou YJ, Song W, Yin Z, He AD,Ming ZY*(明章银).Pharmacological actions of neferine in the modulation of human platelet function.Eur J Pharmacol. 2019 Nov 5;862:172626. doi: 10.1016/j. (IF= 5.195)

5.Song W, Ma YY, Miao S, Yang RP, Zhu Y, Shu D, Lu M, Ma R,Ming ZY*(明章银).Pharmacological actions of miltirone in the modulation of platelet function.Acta Pharmacol Sin.2019 Feb;40(2):199-207.(IF= 7.169)

6.Miao S, Shu D, Zhu Y, Lu M, Zhang Q, Pei Y, He AD, Ma R, Zhang B,Ming ZY*(明章银).Cancer cell-derived immunoglobulin G activates platelets by binding to platelet FcγRIIa.Cell Death Dis. 2019 Jan 28;10(2):87.(IF= 9.685)

7.He AD, Xie W, Song W, Ma YY, Liu G, Liang ML, Da XW, Yao GQ, Zhang BX, Gao CJ, Xiang JZ,Ming ZY*(明章银).Platelet releasates promote the proliferation of hepatocellular carcinoma cells by suppressing the expression of KLF6.Sci Rep.2017 Jun 21;7(1):3989.(IF= 4.996)

8.Yin Z, Xu HJ, Yao XL, Liu G, Nie CJ, Wei H, Li C, Liang ML,Ming ZY*(明章银), Zhang XJ*.Ambient fine particles (PM2.5 ) attenuate collagen-induced platelet activation through interference of the PLCγ2/Akt/GSK3β signalingpathway.Environ Toxicol.2017 Feb;32(2):530-540.(IF= 4.109)

9,.Liu G, Xie W, He AD, Da XW, Liang ML, Yao GQ, Xiang JZ, Gao CJ,Ming ZY*(明章银).Antiplatelet activity of chrysin via inhibiting platelet αIIbβ3-mediated signaling pathway.Mol Nutr Food Res.2016 Sep;60(9):1984-93.doi: 10.1002/mnfr.201500801.(IF= 6.575)

10.Liang ML, Da XW, He AD, Yao GQ, Xie W, Liu G, Xiang JZ,Ming ZY*(明章银).Pentamethylquercetin (PMQ) reduces thrombus formation by inhibiting platelet function.Sci Rep.2015 Jun 10;5:11142.doi: 10.1038/srep11142.(IF= 4.996)

11.Hao HZ, He AD, Wang DC, Yin Z, Zhou YJ, Liu G, Liang ML, Da XW, Yao GQ, Xie W, Xiang JZ,Ming ZY*(明章银).Antiplatelet activity of loureirin A by attenuating Akt phosphorylation: In vitro studies.Eur J Pharmacol.2015 Jan 5;746:63-9.(IF= 5.195)

12.Xiang K, Liu Gang, Zhou YJ, Hao HZ, Yin Z, He AD, Da XW Xiang JZ, Wang J,Ming ZY*(明章银).2,3,5,4’- tetrahydroxystilbene -2-O-β -D- glucoside (THSG) attenuates human platelet aggregation, secretion and spreading in vitro.Thromb Res.2014 Feb; 133 (2):211-7.(IF= 10.407)

13.Zhou YJ, Xiang JZ, Yuan H, Liu H, Tang Q, Hao HZ, Yin Z, Wang J,Ming ZY*(明章银).Neferine exerts its antithrombotic effect by inhibiting platelet aggregation and promoting dissociation of platelet aggregates.Thromb Res.2013 Aug;132(2):202-10.(IF= 10.407)

14.Ming Z(明章银), Hu Y, Xiang J, Polewski P, Newman PJ, Newman DK.Lyn and PECAM-1 function as interdependent inhibitors of platelet aggregation.Blood.2011; 117 (14):3903-6.(IF=25.476)

五、所获奖励：

1.“倒卵叶五加总皂甙对心、脑血管疾病的防治作用”获湖北省自然科学奖三等奖，参与，2004年

2.“血栓性疾病的早期诊断和靶向治疗”获教育部科技进步一等奖，参与，2015年

3.“Lyn and PECAM-1 function as interdependent inhibitors of platelet aggregation.Blood. 2011; 117 (14):3903-6.”获湖北省第十四届自然科学优秀学术论文一等奖，排名第一，2012年

4.“甲基莲心碱对凝血酶、TXA2类似物和胶原酶诱导的血小板聚集的抑制作用”获第二届全国大学生基础医学创新论坛暨实验设计大赛一等奖，指导教师，2012年

5.中华医学会第十七次全国血栓与止血学术会议最佳论文奖，第一，2019.8

六、会议学术报告：

1.The role of Lyn and PECAM-1 on the platelet negative regulation.第十次全国心血管药理学术会议分组报告，重庆，2010.10.22 -25

2.Effects of neferine on platelet aggregation and disaggregation. 4th International Conference on Drug Discovery and Therapy, Session Lecture, Dubai, United Arab Emirates, 12 Feb-15 Feb, 2012

3.Platelet promotes the proliferation of HepG2 cells through depressed expression of KLF6.2014医学前沿论坛暨第六届中俄医药国际学术论坛分组报告，哈尔滨，2014.7.1-3.

4.抗血小板中药研究：现状及展望，中国药理学会第十三次全国学术大会专题报告，北京，2015.11.3-4

5.血小板活性负性调节机制，2016年全国心脑血管药理学术会议学术报告，杭州，2016.10.14-16

6.Platelet derived TGF-β promote the proliferation of hepatocellular carcinoma cells by suppressing the expression of KLF6. 2017年全国心脑血管药理学术会议专题报告，宁波奉化2017.10 14-17

7.Pharmacological actions of miltirone in the modulation of platelet function.2018“一带一路”国家传统药物药理学学术大会大会报告北京2018.5.6-9

8.Cancer cell derived immunoglobulin G activates platelet via binding platelet FcγRIIa. 2019年27届ISTH会议专题报告澳大利亚墨尔本2019.7.6-10

9.CX3CL1/CX3CR1介导的血小板浸润抑制肝癌生长，中华医学会第17次全国血栓与止血学学术会议，大会报道，天津，2019.8.9-11

10.Platelet GPVI is a mediator of rhabdomyolysis-induced acute kidney injury in mice，第二届太湖国际血栓与止血学术讨论会江苏高校血液学协同创新中心血栓与止血学术会议，大会报告，苏州，2019.1012-13

(updated in July, 2022)