课题组研究方向为代谢性疾病药理学，仿生药剂和器件，药物可控释放等。围绕仿生智能器件/制剂的制备、体内递药效果评价，临床转化潜力评估开展相关研究。在前期研究中，课题组基于仿生矿化及微针技术，（1）制备仿生矿化药物制剂，逆转了肿瘤耐药性；（2）成功构建了血糖响应型微针贴片，便利、长效调控病人血糖；（3）创造超强生物粘附微针药片，实现了大分子药物高效口服递送；（4）发展可富集病毒微针咽拭子提高了新冠病毒检测准确性。这些工作分别以研究及综述论文的形式发表在国际著名学术刊物Sci. Adv., Nat. Commun., Adv. Mater., Nano Today, Matter, ACS Nano，Nano Lett., Theranostics，Adv. Drug Deliv. Rev., Small , J. Control. Release。研究工作被美国国立卫生研究院（NIH）和麻省理工学院（MIT）推荐，并被Cell出版社以及多家媒体相继转载。
代表性论文：
1.Li, Q.#; Xu, R.#; Fan, H.#; Xu, J.; Xu, Y.; Cao, P.; Zhang, Y.; Liang, T.; Zhang, Y.;Chen, W.*; Wang, Z.*; Wang, L.*; Chen, X.*, Smart mushroom-inspired imprintable and lightly detachable (MILD) microneedle patterns for effective COVID-19 vaccination and decentralized information storage.ACS Nano2022,16 (5), 7512-7524.
2.Deng, Y.#; Yang, C.#; Zhu, Y.; Liu, W.; Li, H.; Wang, L.;Chen, W.*; Wang, Z.*; Wang, L.*, Lamprey-teeth-inspired oriented antibacterial sericin microneedles for infected wound healing improvement.Nano Lett.2022,22 (7), 2702-2711.
3.Chen, W.; Wainer, J.; Ryoo, S. W.; Qi, X.; Chang, R.; Li, J.; Lee, S. H.; Min, S.; Wentworth, A.; Collins, J.; Tamang, S.; Ishida, K.; Hayward, A.; Langer, R.; Traverso, G.*, Dynamic omnidirectional adhesive microneedle system for oral macromolecular drug delivery.Sci. Adv.2022, eabk1792.
4.Chen, W.*; Wang, Z.*; Wang, L.*; Chen, X.*, Smart chemical engineering‐based lightweight and miniaturized attachable systems for advanced drug delivery and diagnostics.Adv. Mater.2022,34，2106701.
5.Cai, B.; Gong, Y.; Wang, Z.*; Wang, L.*;Chen, W.*, Microneedle arrays integrated with living organisms for smart biomedical applications.Theranostics2021,11(20), 10012.（封面论文）
6.Chen, W.#; Huang, T.#; Shi, K.; Chu, B.; Qian, Z.*, Chemotaxis-based self-accumulation of surface-engineered mitochondria for cancer therapeutic improvement.Nano Today2020,35, 100966.
7.Chen, W.*; Cai, B.; Geng, Z.; Chen, F.; Wang, Z.*; Wang, L.*; Chen, X.*, Reducing false negatives in COVID-19 testing by using microneedle-based oropharyngeal swabs.Matter2020,3(5), 1589-1600.（封面论文）
8.Chen, W.; Shi, K.; Chu, B.; Wei, X.; Qian, Z.*, Mitochondrial surface engineering for multidrug resistance reversal.Nano Lett.2019,19(5), 2905-2913.
(Updated in June, 2022)
