付琴教授课题组
一、人员组成
教授：付琴
副教授：杨晓燕
二、研究方向
本课题组致力于探索心血管疾病和代谢综合征的发病机制和新的药物靶点，主要研究肾上腺素受体和磷酸二酯酶信号通路在心力衰竭和糖尿病并发症中的调控作用。
三、近年来主持的代表性科研项目
1.国家自然科学基金面上项目：β2肾上腺素受体调控CD36介导的心肌细胞和心脏成纤维细胞代谢重塑在心梗后心衰中的双向作用及机制研究
2.国家自然科学基金面上项目：miR-1调控心脏成纤维细胞代谢重编程对糖尿病心脏纤维化的保护作用与机制研究
3.国家自然科学基金海外及港澳学者合作研究基金延续项目：β2肾上腺素受体依赖性的胰岛素促心肌GLUT4转运对β受体阻滞剂抗糖尿病心力衰竭疗效的影响
4.国家自然科学基金面上项目：PDE4调控的心脏成纤维细胞miR-1应答高胰岛素血症在糖尿病心肌纤维化中的作用机制及干预研究
5.国家自然科学基金面上项目：β2肾上腺素受体依赖性的胰岛素诱导的PDE4在糖尿病心功能不全中的作用
6.国家自然科学基金海外合作项目：神经激素对β肾上腺素受体阻断剂抗心力衰竭疗效的影响
7.国家自然科学基金面上项目:雌激素调控心肌钠钙交换体的信号转导机制
8.国家自然科学基金青年基金:雌激素对心肌L型钙通道调控的信号转导机制
四、代表性论文(#第一作者,*通讯作者)
1.Fu J#, Li L#, Chen L, Su C, Feng X, Huang K, Zhang L*,Yang X*,Fu Q*. PGE2 protects against heart failure through inhibiting TGF-β1 synthesis in cardiomyocytes and crosstalk between TGF-β1 and GRK2. J Mol Cell Cardiol. 2022 Nov; 172:63-77.
2.Xu R#, Fu J#, Hu Y, Yang X, Tao X, Chen L, Huang K,Fu Q*. Roflumilast-Mediated Phosphodiesterase 4D Inhibition Reverses Diabetes-Associated Cardiac Dysfunction and Remodeling: Effects Beyond Glucose Lowering.Diabetes. 2022 May 20:db210898. doi: 10.2337/db21-0898
3.Ren H, Chen Y, Ao Z, Cheng Q, Yang X, Tao H, Zhao L, Shen A, Li P*,Fu Q*.PDE4D binds and interacts with YAP to cooperatively promote HCC progression.Cancer Lett. 2022 Aug 10;541:215749
4.Xu R, Feng S, Chen Y, Ao Z, Su C, Feng X,Fu Q*,Yang X*.Long-Acting β2 Adrenergic Receptor Agonist Ameliorates Imiquimod-Induced Psoriasis-Like Skin Lesion by Regulating Keratinocyte Proliferation and Apoptosis.Front. Pharmacol. 2022 June 20, https://doi.org/10.3389/fphar.2022.865715
5.Tao X, Chen C, Chen Y, Zhang L, Hu J, Yu H, Liang M,Fu Q*, Huang K*. β2-adrenergic receptor promotes liver regeneration partially through crosstalk with c-met.Cell Death Dis. 13, 571 (2022). https://doi.org/10.1038/s41419-022-04998-0
6.Tao X, He H, Peng J, Xu R, Fu J, Hu Y, Li L, Yang X, Feng X, Zhang C, Zhang L, Yu X, Shen A*, Huang K*,Fu Q*. Overexpression of PDE4D in mouse liver is sufficient to trigger NAFLD and hypertension in a CD36-TGF-β1 pathway: therapeutic role of roflumilast.Pharmacol Res. 2022 Jan;175:106004.
7.Xu R#, Gopireddy RR#, Wu Y#, Wu L, Tao X, Shao J, Wang W, Li L, Jovanovic A, Xu B, Kenyon NJ, Lu Q, Xiang YK*,Fu Q*. Hyperinsulinemia promotes heterologous desensitization of β2 adrenergic receptor in airway smooth muscle in obesity.FASEB J. 2020 Mar;34(3):3996-4008.
8.Tao X, Hu Y, Li L, Xu R, Fu J, Tong Q*,Fu Q*. Genetic deletion of β(2) adrenergic receptors exacerbates hepatocellular lipid accumulation in high-fat diet mice.BiochemBiophys Res Commun. 2019 Mar 26;511(1):73-78.
9.Fu Q*, Wang Q*, Xiang YK*Insulin and β Adrenergic Receptor Signaling: Crosstalk in Heart.Trends EndocrinolMetab. 2017 Jun;28(6):416-427 .
10.Wang Q#, Liu Y#,Fu Q#, Xu B, Zhang Y, Kim S, Tan R, Barbagallo F, West T, Anderson E, Wei W, Abel ED, Xiang YK. Inhibiting Insulin-Mediated β2-Adrenergic Receptor Activation Prevents Diabetes-Associated Cardiac Dysfunction.Circulation. 2017 Jan 3;135(1):73-88.
11.Fu Q#*,Kim S#, Soto D, De Arcangelis V, Dipilato L, Liu S, Xu B, Zhang J, Shi Q, Xiang YK*. A long-lasting β1 adrenergic receptor stimulation of cAMP/PKA signals in cardiac myocytes. J Biol Chem.2014 May 23;289(21):14771-81
12.Fu Q, Xu B, Liu Y, Parikh D, Li J, Li Y, Zhang Y, Riehle C, Zhu Y, Rawlings T, Shi Q, Clark RB, Chen X, Abel ED, Xiang YK. Insulin inhibits cardiac contractility by inducing a Gi-biased β2 adrenergic signaling in hearts.Diabetes.2014 Aug;63(8):2676-89
13.Fu Q*, Hu Y, Wang Q, Liu Y, Li N, Xu B, Kim S, Chiamvimonvat N, Xiang YK*. High-fat diet induces protein kinase A and G-protein receptor kinase phosphorylation of β(2) -adrenergic receptor and impairs cardiac adrenergic reserve in animal hearts.J Physiol. 2017 Mar 15;595(6):1973-1986.
14.Fu Q, Shi Q, West TM, Xiang YK. Cross-talk between insulin signaling and GPCRs.J CardiovascPharmacol. 2017 Aug;70(2):74-86.
15.Fu Q, Xiang YK. Trafficking of β-Adrenergic Receptors: implications in intracellular receptor signaling.ProgMolBiolTransl Sci.2015;132:151-88
16.Fu Q*, Xu B, Parikh D, Cervantes D, Xiang YK. Insulin induces IRS2-dependent and GRK2-mediated β2AR internalization to attenuate βAR signaling in cardiomyocytes.Cell Signal.2015 Mar;27(3):707-15
17.Fu Q, Chen X, Xiang YK. Compartmentalization of β-adrenergic signals in cardiomyocytes.Trends Cardiovasc Med.2013 Oct;23(7):250-6
18.Zhang Q, Xiang J, Wang X, Liu H, Hu B, Feng M,Fu Q*. Beta(2)-adrenoceptor agonist clenbuterol reduces infarct size and myocardial apoptosis after myocardial ischaemia/reperfusion in anaesthetized rats.Br J Pharmacol. 2010 160(6):1561-72.
19.Li Y, Wei X, Liu S, Zhao Y, Jin S*,Yang X*. Salidroside protects cardiac function in mice with diabetic cardiomyopathy via activation of mitochondrial biogenesis and SIRT3.Phytother Res. 2021 Aug;35(8):4579-4591
20.Bai X#, Yang X#, Jia X#, Rong Y, Chen L, Zeng T, Deng X, Li W, Wu G, Wang L, Li Y, Zhang J, Xiong Z, Xiong L, Wang Y, Zhu L, Zhao Y, Jin S. CAV1-CAVIN1-LC3B- mediated autophagy regulates high glucose-stimulated LDL transcytosis.Autophagy.2020 Jun;16(6):1111-1129
21.Bian F#,Yang XY#, Xu G, Zheng T, Jin S*. CRP-induced NLRP3 inflammasome activation increases LDL transcytosis across endothelial cells.Front Pharmacol. 2019 Jan 30; 10:40. doi: 10.3389/fphar.2019.00040.
22.Zheng T*,Yang XY#, Li WJ, Wang QB, Chen L, Wu D, Bian F, Xing SS, Jin S*. Salidroside Attenuates High-Fat Diet-Induced Nonalcoholic Fatty Liver Disease via AMPK-Dependent TXNIP/NLRP3 Pathway.Oxid Med Cell Longev.2018;2018::8597897.
23.Yang XY, Mao X, Xu G, Xing S, Chattopadhyay A, Jin S*, Salama G*. Estradiol up-regulates L-type Ca2+ channels via membrane-bound estrogen receptor/phosphoinositide-3-kinase/Akt/cAMP response element-binding protein signaling pathway.Heart Rhythm.2018 May;15(5):741-749.
24.Li JY#,Yang XY#, Wang XF, Jia X, Wang ZJ, Deng AP, Bai XL, Zhu L, Li BH, Feng ZB, Li Y, Wang L, Jin S*.Siglec-5 is a novel marker of critical limb ischemia in patients with diabetes.Sci Rep.2017 Sep 12;7(1):11272. doi: 10.1038/s41598-017-11820-x.
25.Li W#,Yang XY#,Zheng T,Xing S,Wu Y,Bian F,Wu G,Li Y,Li J,Bai X,Wu D,Jia X,Wang L,Zhu L,Jin S*. TNF-α stimulates endothelial palmitic acid transcytosis and promotes insulin resistance.Sci Rep.2017 Mar 17; 7:44659.
26.Wu D#,Yang XY#, Zheng T, Xing S, Wang J, Chi J, Bian F, Li W, Xu G, Bai X, Wu G, Jin S*. A novel mechanism of action for salidroside to alleviate diabetic albuminuria: effects on albumin transcytosis across glomerular endothelial cells.Am J PhysiolEndocrinolMetab.2016 Feb 1;310(3): E225-37.
27.Zheng T#,Yang XY#, Wu D, Xing S, Bian F, Li W, Chi J, Bai X, Wu G, Chen X, Zhang Y, Jin S*. Salidroside ameliorates insulin resistance through activation of a mitochondria-associated AMPK/PI3K/Akt/GSK3β pathway.Br J Pharmacol.2015 Jul;172(13):3284-301.
28.Xing SS#,Yang XY#, Zheng T, Li WJ, Wu D, Chi JY, Bian F, Bai XL, Wu GJ, Zhang YZ, Zhang CT, Zhang YH, Li YS, Jin S*. Salidroside improves endothelial function and alleviates atherosclerosis by activating a mitochondria-related AMPK/PI3K/Akt/eNOS pathway.VasculPharmacol.2015 Sep; 72:141-52.
29.Zhang Y#,Yang XY#, Bian F, Wu P, Xing S, Xu G, Li W, Chi J, Ouyang C, Zheng T, Wu D, Zhang Y, Li Y, Jin S*. TNF-α promotes early atherosclerosis by increasing transcytosis of LDL across endothelial cells: crosstalk between NF-κB and PPAR-γ.J Mol Cell Cardiol.2014; 72: 85-94.
30.Bian F#,Yang XY#, Zhou F, Wu PH, Xing S, Xu G, Li W, Chi J, Ouyang C, Zhang Y, Xiong B, Li Y, Zheng T, Wu D, Chen X, Jin S*. CRP promotes atherosclerosis by increasing LDL transcytosis across endothelial cells.Br J Pharmacol.2014; 171(10):2671-84.
31.Xing S#,Yang XY#, Li W, Bian F, Wu D, Chi J, Xu G, Zhang Y, Jin S*. Salidroside stimulates mitochondrial biogenesis and protects against H2O2-induced endothelial dysfunction.Oxid Med Cell Longev.2014; 2014:904834.
32.Li W#,Yang X#, Xing S, Bian F, Yao W, Bai X, Zheng T, Wu G, Jin S*. Endogenous ceramide contributes to the transcytosis of oxLDL across endothelial cells and promotes its subendothelial retention in vascular wall.Oxid Med Cell Longev.2014; 2014:823071. doi: 10.1155/2014/823071.
33.Yang XY#，Chen GJ#, Papp R, Defranco DB, Zeng FD, Salama G*.Oestrogen upregulates L-type Ca2+ channels via oestrogen-receptor- by a regional genomic mechanism in female rabbit hearts.J Physiol.2012;590(3):493-508.
34.Liu QN, Mao XF, Zeng FD, Jin S,Yang XY#. Effect of daurisoline on HERG channel electrophysiological function and protein expression.J Nat Prod, 2012; 75(9):1539-1545.
35.Chen GJ#,Yang XY#，Alber S,Shusterman V,Salama G*. Regional genomic regulation of cardiac sodium-calcium exchanger by oestrogen.J Physiol.2011; 589(5):1061-1080. (IF:4.54)
36.Yang XY，Liu QN，Zhang L, Jiang SQ, Gong PL*. Neuroprotective effect of dauricine after transient middle cerebral artery occlusion in rats: involvement of Bcl-2 family proteins.Am J Chin Med.2010; 38(2):307-318. I
37.Liu QN, Zhang L, Gong PL,Yang XY*, Zeng FD*. Daurisoline suppressed early afterdepolarizations and inhibited L-type calcium current.Am J Chin Med; 2010, 38(1): 37-49.
（Updated in March, 2023）
