郭莲军（1953.12-）
E-mail：gljy2008@126.com
个人简介：药理学教授,博士生导师。华中科技大学同济医学院药理学教授，享受国务院政府津贴。1990年10月赴奥地利因斯布鲁克大学药理学与毒理学研究所学习，在该所所长A.Philippu教授的指导下，完成了“下丘脑GABA能神经对外周动脉血压的调控”的研究工作。1993年回国，在我校药理学教研室开始开展有关心脑血管药理方面的研究工作，建立了相关的实验室和实验方法，并先后多次赴德国进行学术访问和研修，与德国慕尼黑大学及美因茨大学保持有良好的合作关系。主持和参与完成国家自然科学基金课题8项，省部级科研课题7项。主要研究方向HCN通道在脑缺血所致神经细胞与认知功能损伤中作用；抗脑缺血药物作用及机制研究，并开展有关抗脑缺血新药的开发研究。其研究成果于1999年获卫生部科技成果进步奖三等奖，与他人协作完成的课题分别于2000年获湖北省及武汉市科技进步二、三等奖各一项；2005年获国家教学改革成果奖二等奖；主编的《传出神经系统药物药理实验》于2005年在中华医学会第五届全国教育技术学术大会上获优秀电视教材三等奖。已培养博士生20名，硕士生40名，国内外杂志发表科研及教学论文100余篇。
研究方向：脑缺血机制研究及有关抗脑缺血新药的开发研究
代表性论文
1. Activation of GABAB receptors ameliorates cognitive impairment via restoring the balance of HCN1/HCN2 surface expression in the hippocampal CA1 area in rats with chronic cerebral hypoperfusion. Li CJ, Lu Y, Zhou M, Zong XG, Li C, Xu XL,Guo LJ*,Lu Q. Mol Neurobiol. 2014 Oct;50(2):704-20.
2.Astrocytic Toll-like receptor 3 is associated with ischemic preconditioning -induced protection against brain ischemia in rodents. Pan LN, Zhu W, Li Y, Xu XL,Guo LJ, Lu Q, Wang J. PLoS One. 2014 Jun 10;9(6):e99526.
3. Imbalance of HCN1 and HCN2 expression in hippocampal CA1 area impairs spatial learning and memory in rats with chronic morphine exposure. Zhou M, Luo P, Lu Y, Li CJ, Wang DS, Lu Q, Xu XL, He Z,Guo LJ*. Prog Neuropsychopharmacol Biol Psychiatry. 2014 Oct 7;56C:207-214.
4.Electrophysiological properties of hippocampal-cortical neural networks, role in the processes of learning and memory in rats. Li CJ, Lu Y, Zhou M,Guo LJ*. J Neural Transm. 2014 Jun;121(6):583-92.
5. KCNQ/Kv7 channel activator flupirtine protects against acute stress-induced impairments of spatial memory retrieval and hippocampal LTP in rats. Li C, Huang P, Lu Q, Zhou M,Guo L, Xu X. Neuroscience. 2014 Sep 16;280C:19-30.
6 Low Dose ZD7288 Attenuates the Ischemia/Reperfusion-Induced Impairment of Long-Term Potentiation Induction at Hippocampal Schaffer Collateral-CA1 Synapses. Wei He. Xulin Xu . Qing Lv .Lianjun Guo*. Cellular and Molecular Neurobiology: 2014，34（4）：611-617
7.Pan Luo，Yun Lu，Changjun Li，Mei Zhou，Cheng Chen，Qing Lu，Xulin Xu，Zhi He，Lianjun Guo*.Long-lasting spatial learning and memory impairments caused by chronic cerebral hypoperfusion associate with a dynamic change of HCN1/HCN2 expression in hippocampal CA1 region. Neurobiology of Learning and Memory.2015,123:72-83.
8.Yun Lu, Changjun Li , Mei Zhou, Pan Luo, Pengcheng Huang, Jiahong Tan, Qing Lu, Xulin Xu,Zhi He ,Lianjun Guo*.Clonidine ameliorates cognitive impairment induced by chronic cerebral hypoperfusion via up-regulation of the GABABR1 and GAD67 in hippocampal CA1 in rats. Pharmacology, Biochemistry and Behavior 132 (2015) 96–102.
9. Mei Zhou, Pan Luo, Yun Lu , Chang-jun Li, Dian-shiWang , Qing Lu, Xu-lin Xu,Zhi He,Lian-jun Guo* Imbalance of HCN1 and HCN2 expression in hippocampal CA1 area impairs spatial learning and memory in rats with chronic morphine exposure. Progress in Neuro-Psychopharmacology & Biological Psychiatry 56 (2015) 207–214.
10. Pan Luo andLianjun Guo*.HCN Channels: From the Role in Chronic Cerebral Hypoperfusion-Induced Cognitive Impairments to a New Therapeutic Target for Vascular Dementia. Neurology & Neurophysiology 2015.6（4）：1-6 .
11. Li Y, Xu XL, Zhao D, Pan LN, Huang CW,Guo LJ, Lu Q, Wang J.TLR3 ligand Poly IC Attenuates Reactive Astrogliosis and Improves Recovery of Rats after Focal Cerebral Ischemia. CNS Neurosci Ther. 2015 Nov;21(11):905-13.
12. Li C, Lu Q, Huang P, Fu T, Li C,Guo L, Xu X.Activity-dependent downregulation of M-Type (Kv7) K⁺ channels surface expression requires the activation of iGluRs/Ca²⁺/PKC signaling pathway in hippocampal neuron. Neuropharmacology. 2015 Aug;95:154-67.
13. Huang P, Li C, Fu T, Zhao D, Yi Z, Lu Q,Guo L,Xu X. Flupirtine attenuates chronic restraint stress-induced cognitive deficits and hippocampal apoptosis in male mice.Behav Brain Res. 2015 Jul 15;288:1-10.
14.Lu Y, Li CJ, Chen C, Luo P, Zhou M, Li C, Xu XL, Lu Q, He Z,Guo LJ*.Activation of GABAB2 subunits alleviates chronic cerebral hypoperfusion-induced anxiety-like behaviours: A role for BDNF signalling and Kir3 channels. Neuropharmacology. 2016 Nov;110(Pt A):308-21.
15.Luo P, Chen C, Lu Y, Fu T, Lu Q, Xu X, Li C, He Z,Guo L*Baclofen ameliorates spatial working memory impairments induced by chronic cerebral hypoperfusion via up-regulation of HCN2 expression in the PFC in rats.Behav Brain Res(0166-4328). 2016 Jul 15;308:6-13.
16.Luo P, Zhang X, Lu Y, Chen C, Li C, Zhou M, Lu Q, Xu X, Shen G4,Guo L*.
Fluoxetine ameliorates cognitive impairments induced by chronic cerebral hypoperfusion via down-regulation of HCN2 surface expression in the hippocampal CA1 area in rats.Pharmacology, Biochemistry and Behavior.2016 Jan;140:1-7
承担的主要科研项目：
1、国家自然科学基金：Ih通道对脑缺血海马NMDA受体亚型功能性重组的调节
2、国家自然科学基金：脑缺血时海马HCN1通道改变对谷氨酸释放的影响
3、国家自然科学基金：脑缺血时兴奋性与抑制性氨基酸受体间对话研究
4、国家自然科学基金：慢性脑低灌损伤HCN2对海马GABA抑制性中间神经元突触可塑性的修饰调节
专利
专利名称：米邦塔仙人掌多糖在防治慢性神经退行性疾病中的应用 专利申请号：2010101995305
奖励与荣誉：
卫生部科技成果进步奖三等奖：下丘脑氨基酸类神经递质释放特点
